ArticleJournal of endocrinological investigation2015
Pregnancy outcome in women treated with methimazole or propylthiouracil during pregnancy.
Article in Journal of endocrinological investigation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Pooled it
- Efficacy of propylthiouracil in the treatment of pregnancy with hyperthyroidism and its effect on pregnancy outcomes: A meta-analysis.PloS one · 2022Pooled it
- Pooled it
- Review
- Article
- Compensatory mechanisms in response to induced hypothyroidism in the late gestation pig fetus†.Biology of reproduction · 2023Article
- Application of oral inorganic iodine in the treatment of Graves' disease.Frontiers in endocrinology · 2023Review
- Pregnancy Outcomes among Women with Graves' Hyperthyroidism: A Retrospective Cohort Study.Journal of clinical medicine · 2021Article
- Exposure to Propylthiouracil in the First Trimester of Pregnancy and Birth Defects: A Study at a Single Institution.Journal of the Endocrine Society · 2021Article
- The various faces of hyperthyroidism.Journal of clinical & translational endocrinology · 2020Article
- Treatment of Graves' hyperthyroidism with thionamides: a position paper on indications and safety in pregnancy.Journal of endocrinological investigation · 2020Review
- Antithyroid drugs and birth defects.Thyroid research · 2020Review
- Hyperthyroid heart disease in pregnancy: Retrospective analysis of a case series and review of the literature.World journal of clinical cases · 2019Article
- Hyperthyroidism in the pregnant woman: Maternal and fetal aspects.Journal of clinical & translational endocrinology · 2019Review
- Graves' hyperthyroidism in pregnancy: a clinical review.Clinical diabetes and endocrinology · 2018Review
- Thyroid Medication Use and Birth Defects in the National Birth Defects Prevention Study.Birth defects research · 2017Article
- Management of hyperthyroidism due to Graves' disease: frequently asked questions and answers (if any).Journal of endocrinological investigation · 2016Review
- Hyperthyroidism.Lancet (London, England) · 2016Review
- Congenital Bands with Intestinal Malrotation after Propylthiouracil Exposure in Early Pregnancy.Case reports in endocrinology · 2015Article
Corrections and comments
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Authors and funding
15 authors at 9 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeControl of thyroid function in hyperthyroid women during pregnancy is based on antithyroid drugs (ATD) [propylthiouracil (PTU) and methimazole (MMI)]. While a teratogenic effect has been suggested for MMI and, more recently, for PTU, a clear demonstration is still lacking. Aim of this study was to assess the safety of ATD during pregnancy.
methodsA total of 379 pregnancies were retrospectively recruited in eight Italian Departments of Endocrinology and divided in five groups: (1) MMI-treated and euthyroid throughout pregnancy (n = 89); (2) MMI-treated and hyperthyroid on at least two occasions (n = 35); (3) PTU-treated women and euthyroid throughout pregnancy (n = 32); (4) PTU-treated women and hyperthyroid on at least two occasions (n = 20); and (5) non-ATD-treated (n = 203). Data on maternal thyroid function, miscarriages, type of delivery, neonatal weight, length and TSH, perinatal complications and congenital malformation were analyzed.
resultsThe gestational age at delivery, the rate of vaginal delivery, neonatal weight, length and neonatal TSH did not significantly differ among groups. In all groups, the rates of spontaneous miscarriage and of major congenital malformations were not higher than in the general population. No newborns were born with a phenotype similar to those described in the "MMI embryopathy".
conclusionsWhile a clear demonstration of a teratogenic effect of MMI is currently lacking, it seems reasonable to follow the current guidelines and advice for PTU treatment in hyperthyroid women during the first trimester of pregnancy. Further, large and prospective worldwide studies will be needed to fully clarify the issue of ATD safety during pregnancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.