ArticleDrug and alcohol dependence2015
Denial in methamphetamine users: Associations with cognition and functional connectivity in brain.
Article in Drug and alcohol dependence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 54 citations in OpenAlex.
- Functional Brain Network Predictors of Abstinence Treatment Outcomes in Methamphetamine Use Disorder.CNS neuroscience & therapeutics · 2026Article
- IL-6 Expression and the Confidence Interval-Based Estimation of Relevance (CIBER) Help Identify Persistent Inflammation and Cognitive Parameters of Executive Dysfunction in the Withdrawal Phase of Male Polydrug Abusers.Healthcare (Basel, Switzerland) · 2025Article
- Perirhinal to prefrontal circuit in methamphetamine induced recognition memory deficits.Neuropharmacology · 2023Article
- Neurophysiological error processing and addiction self-awareness correlates of reduced insight in cannabis use disorder.Addiction (Abingdon, England) · 2023Article
- Review
- A brainnetome atlas-based methamphetamine dependence identification using neighborhood component analysis and machine learning on functional MRI data.Frontiers in cellular neuroscience · 2022Article
- Denial and Diagnosis of Methamphetamine Dependence Severity.Substance abuse : research and treatment · 2022Article
- Neural and Behavioral Correlates of Impaired Insight and Self-Awareness in Substance Use Disorder.Current behavioral neuroscience reports · 2021Article
- Methamphetamine Dysregulation of the Central Nervous System and Peripheral Immunity.The Journal of pharmacology and experimental therapeutics · 2021Review
- Neurocognitive Empowerment for Addiction Treatment (NEAT): study protocol for a randomized controlled trial.Trials · 2021Article
- CYP2D6 genotype may moderate measures of brain structure in methamphetamine users.Addiction biology · 2021Article
- Age Influences Loss Aversion Through Effects on Posterior Cingulate Cortical Thickness.Frontiers in neuroscience · 2021Article
- Self-awareness of problematic drug use: Preliminary validation of a new fMRI task to assess underlying neurocircuitry.Drug and alcohol dependence · 2020Article
- Behavioral preference for viewing drugPsychological medicine · 2020Article
- Validation of a health screening questionnaire for primary care using Rasch models.Journal of patient-reported outcomes · 2019Article
- Cognitive deficit in methamphetamine users relative to childhood academic performance: link to cortical thickness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- A Comparison Study of Working Memory Deficits between Patients with Methamphetamine-Associated Psychosis and Patients with Schizophrenia.Shanghai archives of psychiatry · 2018Article
- The relationship between interleukin-6 and functional connectivity in methamphetamine users.Neuroscience letters · 2018Article
- Neural underpinnings of maladaptive decision-making in addictions.Pharmacology, biochemistry, and behavior · 2018Review
- Medications for substance use disorders (SUD): emerging approaches.Expert opinion on emerging drugs · 2017Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDespite harmful consequences of drug addiction, it is common for individuals with substance use disorders to deny having problems with drugs. Emerging evidence suggests that some drug users lack insight into their behavior due to neurocognitive dysfunction, but little research has examined potential neurocognitive contributions to denial.
methodsThis study explored the relationship between denial, cognitive performance and functional connectivity in brain. The participants were 58 non-treatment-seeking, methamphetamine-dependent participants who completed the URICA precontemplation scale, a self-report measure of denial of drug problems warranting change, as well as a cognitive test battery. A subset of participants (N = 21) had functional MRI scans assessing resting-state functional connectivity. Given literature indicating roles of the rostral anterior cingulate (rACC), anterior insula and precuneus in self-awareness, relationships between denial and resting-state connectivity were tested using seeds placed in these regions.
resultsThe results revealed a negative relationship between denial and an overall cognitive battery score (p = 0.001), the effect being driven particularly by performance on tests of memory and executive function. Denial was negatively associated with strength of connectivity between the rACC and regions of the frontal lobe (precentral gyri, left ventromedial prefrontal cortex, left orbitofrontal cortex), limbic system (left amygdala, left hippocampus and left parahippocampal gyrus), occipital lobes and cerebellum; and between the precuneus and the midbrain and cerebellum. Anterior insula connectivity was unrelated to denial.
conclusionsThese findings suggest that denial by methamphetamine users is linked with a cognitive and neural phenotype that may impede the development of insight into their behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.