ArticleACS nano2015
Controlling differentiation of adipose-derived stem cells using combinatorial graphene hybrid-pattern arrays.
Article in ACS nano, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 145 citations in OpenAlex.
- Graphene-based materials: an innovative approach for neural regeneration and spinal cord injury repair.RSC advances · 2025Review
- Application of Adipose Extracellular Matrix and Reduced Graphene Oxide Nanocomposites for Spinal Cord Injury Repair.Advanced healthcare materials · 2025Article
- Guiding Cell Growth: Graphene-Patterned Polymeric Substrates for Enhanced Tissue Proliferation.Nanotechnology, science and applications · 2025Article
- Effects of polylactic acid scaffolds with various orientations and diameters on osteogenesis and angiogenesis.Frontiers in bioengineering and biotechnology · 2024Article
- How Mechanical and Physicochemical Material Characteristics Influence Adipose-Derived Stem Cell Fate.International journal of molecular sciences · 2023Review
- Non-electric bioelectrical analog strategy by a biophysical-driven nano-micro spatial anisotropic scaffold for regulating stem cell niche and tissue regeneration in a neuronal therapy.Bioactive materials · 2023Article
- Bioactive graphene oxide-functionalized self-expandable hydrophilic and osteogenic nanocomposite for orthopaedic applications.Materials today. Bio · 2023Article
- Graphene Oxide/Gelatin Nanofibrous Scaffolds Loaded with N-Acetyl Cysteine for Promoting Wound Healing.International journal of nanomedicine · 2023Article
- Extrapolating neurogenesis of mesenchymal stem/stromal cells on electroactive and electroconductive scaffolds to dental and oral-derived stem cells.International journal of oral science · 2022Review
- Phenotypic change of mesenchymal stem cells into smooth muscle cells regulated by dynamic cell-surface interactions on patterned arrays of ultrathin graphene oxide substrates.Journal of nanobiotechnology · 2022Article
- Immobilization of modular peptides on graphene cocktail for differentiation of human mesenchymal stem cells to hepatic-like cells.Frontiers in chemistry · 2022Article
- Graphene-Based Materials for Efficient Neurogenesis.Advances in experimental medicine and biology · 2022Article
- Nano-sized graphene oxide coated nanopillars on microgroove polymer arrays that enhance skeletal muscle cell differentiation.Nano convergence · 2021Article
- Mineralized collagen scaffold bone graft accelerate the osteogenic process of HASCs in proper concentration.Regenerative therapy · 2021Article
- CircRNA-23525 regulates osteogenic differentiation of adipose-derived mesenchymal stem cells via miR-30a-3p.Cell and tissue research · 2021Article
- Electrochemical Cell Chips Based on Functionalized Nanometals.Frontiers in chemistry · 2021Review
- Graphene Oxide-Based Nanomaterials: An Insight into Retinal Prosthesis.International journal of molecular sciences · 2020Review
- Understanding cellular interactions with nanomaterials: towards a rational design of medical nanodevices.Nanotechnology · 2020Review
- 3D Printing of Cytocompatible Graphene/Alginate Scaffolds for Mimetic Tissue Constructs.Frontiers in bioengineering and biotechnology · 2020Article
- Enhancing Neurogenesis of Neural Stem Cells Using Homogeneous Nanohole Pattern-Modified Conductive Platform.International journal of molecular sciences · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Control of stem cell fate by modulating biophysical cues (e.g., micropatterns, nanopatterns, elasticity and porosity of the substrates) has emerged as an attractive approach in stem cell-based research. Here, we report a method for fabricating combinatorial patterns of graphene oxide (GO) to effectively control the differentiation of human adipose-derived mesenchymal stem cells (hADMSCs). In particular, GO line patterns were highly effective for modulating the morphology of hADMSCs, resulting in enhanced differentiation of hADMSCs into osteoblasts. Moreover, by generating GO grid patterns, we demonstrate the highly efficient conversion of mesodermal stem cells to ectodermal neuronal cells (conversion efficiency = 30%), due to the ability of the grid patterns to mimic interconnected/elongated neuronal networks. This work provides an early demonstration of developing combinatorial graphene hybrid-pattern arrays for the control of stem cell differentiation, which can potentially lead to more effective stem cell-based treatment of incurable diseases/disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.