SynthesisEuropean journal of orthodontics2016
Meta-analysis and systematic review of the number of non-syndromic congenitally missing permanent teeth per affected individual and its influencing factors.
Synthesis in European journal of orthodontics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Hypodontia in the Korean orthodontic population: Prevalence and characteristics of a nationwide multicenter study.Korean journal of orthodontics · 2026Article
- Prevalence of lower second premolar agenesis and study of rhizolysis of primary second molars without permanent successor with 2 methods.Oral radiology · 2026Article
- Genetic Aspects of Tooth Agenesis.Genes · 2025Review
- Dental Anomalies in Primary Dentition among Arabian Children: A Hospital-Based Study.Children (Basel, Switzerland) · 2024Article
- Tooth agenesis: An overview of diagnosis, aetiology and management.The Japanese dental science review · 2023Review
- Patterns of nonsyndromic tooth agenesis and sexual dimorphism.BMC oral health · 2023Article
- Non-syndromic familial congenital dental deficiency: two cases report.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2022Article
- Congenitally missing second permanent molars in non-syndromic patients (Review).Experimental and therapeutic medicine · 2022Review
- Consecutive tooth agenesis patterns in non-syndromic oligodontia.Odontology · 2022Article
- Radiographic evaluation of non-syndromic third molar agenesis in two Mediterranean populations.Medicine and pharmacy reports · 2021Article
- Study of rs12532, rs8670 Polymorphism of Msh Homeobox 1 (MSX1), rs61754301, rs4904155 Polymorphism of Paired Box Gene 9 (PAX9), and rs2240308 Polymorphism of Axis Inhibitor Protein 2 (AXIN2) Genes in Nonsyndromic Hypodontia.BioMed research international · 2019Article
- Prevalence of Hypodontia in a Sample of Spanish Dental Patients.Acta stomatologica Croatica · 2018Article
- Epidemiological survey on third molar agenesis and facial pattern among adolescents requiring orthodontic treatment.Journal of clinical and experimental dentistry · 2017Article
- A Rare Incidence of Nonsyndromic Mandibular Incisor Agenesis in a Three-generation Family: Case Report and Literature Review.International journal of clinical pediatric dentistryArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeDental aplasia (or hypodontia) is a frequent and challenging anomaly and thus of interest to many dental fields. Although the number of missing teeth (NMT) in each person is a major clinical determinant of treatment need, there is no meta-analysis on this subject. Therefore, we aimed to investigate the relevant literature, including epidemiological studies and research on dental/orthodontic patients.
methodsAmong 50 reports, the effects of ethnicities, regions, sample sizes/types, subjects' minimum ages, journals' scientific credit, publication year, and gender composition of samples on the number of missing permanent teeth (except the third molars) per person were statistically analysed (α = 0.05, 0.025, 0.01). LIMITATIONS: The inclusion of small studies and second-hand information might reduce the reliability. Nevertheless, these strategies increased the meta-sample size and favoured the generalisability. Moreover, data weighting was carried out to account for the effect of study sizes/precisions.
resultsThe NMT per affected person was 1.675 [95% confidence interval (CI) = 1.621-1.728], 1.987 (95% CI = 1.949-2.024), and 1.893 (95% CI = 1.864-1.923), in randomly selected subjects, dental/orthodontic patients, and both groups combined, respectively. The effects of ethnicities (P > 0.9), continents (P > 0.3), and time (adjusting for the population type, P = 0.7) were not significant. Dental/orthodontic patients exhibited a significantly greater NMT compared to randomly selected subjects (P < 0.012). Larger samples (P = 0.000) and enrolling younger individuals (P = 0.000) might inflate the observed NMT per person.
conclusionsTime, ethnic backgrounds, and continents seem unlikely influencing factors. Subjects younger than 13 years should be excluded. Larger samples should be investigated by more observers.
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