Trial reportAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology2015
Factors associated with high short-acting β2-agonist use in urban children with asthma.
Trial report in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01981564 (Asthma Express Intervention to Bridge Emergency to Primary Care for High Risk Children With Asthma), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Asthma Express Intervention to Bridge Emergency to Primary Care for High Risk Children With Asthma
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Adverse Outcomes Associated With Short-Acting Beta-Agonist Overuse in Asthma: A Systematic Review and Meta-Analysis.Allergy · 2025Pooled it
- Children with poorly controlled asthma: Randomized controlled trial of a home-based environmental control intervention.Pediatric pulmonology · 2019Trial
- Salivary cotinine measurement for all children with persistent asthma: spit matters.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2016Trial
- Evidence-Based Clinical Recommendations for the Appropriate Use of Diagnostic Tests in Pediatric Allergology: Focus on Asthma, Rhinoconjunctivitis, and Keratoconjunctivitis Vernal.Journal of clinical medicine · 2026Review
- Objective monitoring tools for improved management of childhood asthma.Respiratory research · 2024Review
- Short-acting βERJ open research · 2023Article
- Short-acting βPediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Article
- Prevalence of overuse of short-acting beta-2 agonists (SABA) and associated factors among patients with asthma in Germany.Respiratory research · 2021Article
- The economic burden of medical treatment of children with asthma in China.BMC pediatrics · 2020Article
- Exploring the barriers and incentive architecture for modifying smoke exposures among asthmatics.The Journal of asthma : official journal of the Association for the Care of Asthma · 2019Article
- Factors associated with poor controller medication use in children with high asthma emergency department use.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2017Article
- Caregiver perception of asthma management of children in the context of poverty.The Journal of asthma : official journal of the Association for the Care of Asthma · 2017Article
- Asthma prescribing, ethnicity and risk of hospital admission: an analysis of 35,864 linked primary and secondary care records in East London.NPJ primary care respiratory medicine · 2016Article
- Asthma in Urban Children: Epidemiology, Environmental Risk Factors, and the Public Health Domain.Current allergy and asthma reports · 2016Review
- Impact of family socioeconomic position on childhood asthma outcomes, severity, and specialist referral - a Danish nationwide study.Chronic respiratory diseaseArticle
- Asthma Home Management in the Inner-City: What can the Children Teach us?Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & PractitionersArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundOne goal of guideline-based asthma therapy is minimal use of short-acting β₂ agonist (SABA) medications. Inner-city children with asthma are known to have high SABA use.
objectiveTo examine factors associated with high SABA use in inner-city children with asthma.
methodsOne hundred inner-city children with persistent asthma were enrolled into a randomized controlled trial of an emergency department (ED) and home intervention. All children underwent serologic allergen specific IgE and salivary cotinine testing at the ED enrollment visit. Pharmacy records for the past 12 months were obtained. Number of SABA fills during the past 12 months was categorized into low- to moderate- vs high-use groups. SABA groups were compared by the number of symptom days and nights, allergen sensitization, and exposures. Regression models were used to predict high SABA use.
resultsMean number of SABA fills over 12 months was 3.12. Unadjusted bivariate analysis showed that high SABA users were more than 5 times more likely to have an asthma hospitalization, almost 3 times more likely to have an asthma intensive care unit admission, and more than 3 times more likely to have prior specialty asthma care or positive cockroach sensitization than low to moderate SABA users. In the final regression model, for every additional inhaled corticosteroid fill, a child was 1.4 times more likely and a child with positive cockroach sensitization was almost 7 times more likely to have high SABA use when controlling for prior intensive care unit admission, receipt of specialty care, child age, and income.
conclusionProviders should closely monitor SABA and controller medication use, allergen sensitization, and exposures in children with persistent asthma.
trial registrationClinicalTrials.gov, identifier NCT01981564.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.