ArticleJournal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
Magnetic resonance imaging-measured bone marrow adipose tissue area is inversely related to cortical bone area in children and adolescents aged 5-18 years.
Article in Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03219229 (Metabolic Effects of Differential Organ Growth Rates), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Metabolic Effects of Differential Organ Growth Rates
Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Liver Adiposity and Metabolic Profile in Individuals with Chronic Spinal Cord Injury.BioMed research international · 2017Trial
- Nutrient regulation of bone marrow adipose tissue: skeletal implications of weight loss.Nature reviews. Endocrinology · 2023Review
- 3T-MRI-based age, sex and site-specific markers of musculoskeletal health in healthy children and young adults.Endocrine connections · 2022Article
- Acute Water Supplementation Improved the Body Composition of Young Female Adults After Water Restriction of 12 h in Baoding, China: A Randomized Controlled Trial (RCT).Frontiers in nutrition · 2022Article
- Bone marrow adipose tissue content in Latino adolescents with prediabetes and obesity.Obesity (Silver Spring, Md.) · 2021Article
- Application of Magnetic Resonance Imaging in the Evaluation of Nutritional Status: A Literature Review with Focus on Dialysis Patients.Nutrients · 2021Review
- Exercise Increases Bone in SEIPIN Deficient Lipodystrophy, Despite Low Marrow Adiposity.Frontiers in endocrinology · 2021Article
- Imaging of body composition in children.Quantitative imaging in medicine and surgery · 2020Review
- Quantifying bone marrow fat using standard T1-weighted magnetic resonance images in children with typical development and in children with cerebral palsy.Scientific reports · 2020Article
- The Bones of Children With Obesity.Frontiers in endocrinology · 2020Review
- Erythropoietin modulates bone marrow stromal cell differentiation.Bone research · 2019Article
- Clinical implications of bone marrow adiposity.Journal of internal medicine · 2018Review
- Current body composition measurement techniques.Current opinion in endocrinology, diabetes, and obesity · 2017Review
- Thyroid hormone acting via TRβ induces expression of browning genes in mouse bone marrow adipose tissue.Endocrine · 2017Article
- Changes in Bone Marrow Adipose Tissue in Transgender and Gender Non-Conforming Youth Undergoing Pubertal Suppression: A Pilot Study.Journal of clinical densitometry : the official journal of the International Society for Clinical DensitometryArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Previous studies have shown an inverse correlation between bone marrow adipose tissue and bone mineral density in cancellous bone; however, such relationships in cortical bone are less studied, especially in children. A total of 185 healthy children and adolescents (76 females and 109 males, aged 5-18 years) were included in this study. Right femoral bone marrow adipose tissue area (BMA), right femoral cortical bone area (CBA), subcutaneous adipose tissue, visceral adipose tissue, and skeletal muscle were accessed by whole-body magnetic resonance imaging. In regression analysis with CBA as the dependent variable and BMA as the independent variable, BMA negatively contributed to CBA after adjusting for weight and total body fat or subcutaneous adipose tissue, visceral adipose tissue, and skeletal muscle (β = -0.201 to -0.272, p < 0.001). These results suggest an inverse relationship between BMA and CBA in children and adolescents after adjustment of body weight or body composition. The data support the hypothesis that a competitive relationship exists between bone and marrow fat in cortical bone and is consistent with a similar finding in cancellous bone in previous studies. Future research is needed to clarify the role of marrow fat in childhood fractures that are related to cortical bone quality.
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Registered trials
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