ArticleGenome biology and evolution2015
Recent positive selection has acted on genes encoding proteins with more interactions within the whole human interactome.
Article in Genome biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed.
- The interaction of biological network topology and mutation effects in complex trait evolution.Frontiers in systems biology · 2026Review
- Flexibility in Gene Coexpression at Developmental and Evolutionary Timescales.Molecular biology and evolution · 2025Article
- Adaptation in human immune cells residing in tissues at the frontline of infections.Nature communications · 2024Article
- An efficient and robust ABC approach to infer the rate and strength of adaptation.G3 (Bethesda, Md.) · 2024Article
- Assessing the Presence of Recent Adaptation in the Human Genome With Mixture Density Regression.Genome biology and evolution · 2023Article
- Ortholog genes from cactophilic Drosophila provide insight into human adaptation to hallucinogenic cacti.Scientific reports · 2022Article
- Two decades of suspect evidence for adaptive molecular evolution-negative selection confounding positive-selection signals.National science review · 2022Article
- Dissecting Genomic Determinants of Positive Selection with an Evolution-Guided Regression Model.Molecular biology and evolution · 2022Article
- Article
- An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia.Current biology : CB · 2021Article
- Ancient RNA virus epidemics through the lens of recent adaptation in human genomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Robust inference of positive selection on regulatory sequences in the human brain.Science advances · 2020Article
- Molecular Characterization, Protein-Protein Interaction Network, and Evolution of Four Glutathione Peroxidases fromAntioxidants (Basel, Switzerland) · 2020Article
- Pleiotropy facilitates local adaptation to distant optima in common ragweed (Ambrosia artemisiifolia).PLoS genetics · 2020Article
- Co-expression clustering across flower development identifies modules for diverse floral forms inPeerJ · 2020Article
- Gene connectivity and enzyme evolution in the human metabolic network.Biology direct · 2019Article
- Molecular Chaperones Accelerate the Evolution of Their Protein Clients in Yeast.Genome biology and evolution · 2019Article
- What lies beneath? Molecular evolution during the radiation of caecilian amphibians.BMC genomics · 2019Article
- Evidence that RNA Viruses Drove Adaptive Introgression between Neanderthals and Modern Humans.Cell · 2018Article
- The Diverging Routes of BORIS and CTCF: An Interactomic and Phylogenomic Analysis.Life (Basel, Switzerland) · 2018Article
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6 authors.
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Abstract
Genes vary in their likelihood to undergo adaptive evolution. The genomic factors that determine adaptability, however, remain poorly understood. Genes function in the context of molecular networks, with some occupying more important positions than others and thus being likely to be under stronger selective pressures. However, how positive selection distributes across the different parts of molecular networks is still not fully understood. Here, we inferred positive selection using comparative genomics and population genetics approaches through the comparison of 10 mammalian and 270 human genomes, respectively. In agreement with previous results, we found that genes with lower network centralities are more likely to evolve under positive selection (as inferred from divergence data). Surprisingly, polymorphism data yield results in the opposite direction than divergence data: Genes with higher centralities are more likely to have been targeted by recent positive selection during recent human evolution. Our results indicate that the relationship between centrality and the impact of adaptive evolution highly depends on the mode of positive selection and/or the evolutionary time-scale.
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