ArticleBioinformatics (Oxford, England)2015
Three minimal sequences found in Ebola virus genomes and absent from human DNA.
Article in Bioinformatics (Oxford, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 50 citations in OpenAlex.
- Article
- Cellular Activity of CQWW Nullomer-Derived Peptides.ACS omega · 2025Article
- The topography of nullomer-emerging mutations and their relevance to human disease.Computational and structural biotechnology journal · 2025Article
- kmerDB: A database encompassing the set of genomic and proteomic sequence information for each species.Computational and structural biotechnology journal · 2024Article
- A survey of k-mer methods and applications in bioinformatics.Computational and structural biotechnology journal · 2024Review
- Article
- Significant non-existence of sequences in genomes and proteomes.Nucleic acids research · 2021Article
- Article
- Absent words and the (dis)similarity analysis of DNA sequences: an experimental study.BMC research notes · 2016Article
- Nullomers and High Order Nullomers in Genomic Sequences.PloS one · 2016Article
- In the search of potential epitopes for Wuhan seafood market pneumonia virus using high order nullomers.Journal of immunological methodsArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
motivationEbola virus causes high mortality hemorrhagic fevers, with more than 25 000 cases and 10 000 deaths in the current outbreak. Only experimental therapies are available, thus, novel diagnosis tools and druggable targets are needed.
resultsAnalysis of Ebola virus genomes from the current outbreak reveals the presence of short DNA sequences that appear nowhere in the human genome. We identify the shortest such sequences with lengths between 12 and 14. Only three absent sequences of length 12 exist and they consistently appear at the same location on two of the Ebola virus proteins, in all Ebola virus genomes, but nowhere in the human genome. The alignment-free method used is able to identify pathogen-specific signatures for quick and precise action against infectious agents, of which the current Ebola virus outbreak provides a compelling example.
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Registered trials
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