Evidence map›Paper›PMID 25839914›Full record

ArticleEnvironmental health perspectives2015

Prenatal and Childhood Traffic-Related Pollution Exposure and Childhood Cognition in the Project Viva Cohort (Massachusetts, USA).

Maria H Harris, Diane R Gold, Sheryl L Rifas-Shiman, Steven J Melly, Antonella Zanobetti, Brent A Coull, Joel D Schwartz, Alexandros Gryparis, Itai Kloog, Petros Koutrakis and 4 more

Erratum issuedAbstract read
In one paragraph

Article in Environmental health perspectives, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 76 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Quantifying the association between PMEnvironmental health : a global access science source · 2024
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Prenatal PMEnvironment & health (Washington, D.C.) · 2024
    Article
  11. Article
  12. PMJournal of exposure science & environmental epidemiology · 2024
    Article
  13. Article
  14. Relation of prenatal and postnatal PMInternational journal of hygiene and environmental health · 2024
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Maria H HarrisDepartment of Environmental Health, Boston University School of Public Health, Boston, Massachusetts, USA.
Diane R Gold
Sheryl L Rifas-Shiman
Steven J Melly
Antonella Zanobetti
Brent A Coull
Joel D Schwartz
Alexandros Gryparis
Itai Kloog
Petros Koutrakis
David C Bellinger
Roberta F White
Sharon K Sagiv
Emily Oken

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
Effect of Ambient Particles on Acute Stroke OnsetP01ES009825 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI GOLD, DIANE R · 1999 to 2009
$17.4M
Environmental Epidemiology in Community SettingsT32ES014562 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Birgit Gunhild Claus Henn · 2006 to 2026
$7.7M
Pre- and Peri-natal Predictors of Childhood ObesityR37HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI GILLMAN, MATTHEW W · 2012 to 2015
$4.5M
The Fetal and Childhood Environment, Oxidative Balance, Inflammation and AsthmaR01AI102960 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLD, DIANE R, OKEN, EMILY · 2013 to 2017
$4.0M
Patient-oriented Research in Maternal Perinatal Overnutrition and Child AdiposityK24HD069408 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2011 to 2015
$844k
NIAID NIH HHS R01 AI102960NIAID NIH HHS R01AI102960NICHD NIH HHS K24 HD069408NICHD NIH HHS K24HD069408NICHD NIH HHS R37 HD034568NICHD NIH HHS R37HD034568NIEHS NIH HHS P01 ES009825NIEHS NIH HHS P01ES009825NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P30ES000002NIEHS NIH HHS T32 ES014562NIEHS NIH HHS T32ES014562
6 · The paper itself

Abstract

backgroundInfluences of prenatal and early-life exposures to air pollution on cognition are not well understood.

objectivesWe examined associations of gestational and childhood exposure to traffic-related pollution with childhood cognition.

methodsWe studied 1,109 mother-child pairs in Project Viva, a prospective birth cohort study in eastern Massachusetts (USA). In mid-childhood (mean age, 8.0 years), we measured verbal and nonverbal intelligence, visual motor abilities, and visual memory. For periods in late pregnancy and childhood, we estimated spatially and temporally resolved black carbon (BC) and fine particulate matter (PM2.5) exposures, residential proximity to major roadways, and near-residence traffic density. We used linear regression models to examine associations of exposures with cognitive assessment scores, adjusted for potential confounders.

resultsCompared with children living ≥ 200 m from a major roadway at birth, those living < 50 m away had lower nonverbal IQ [-7.5 points; 95% confidence interval (CI): -13.1, -1.9], and somewhat lower verbal IQ (-3.8 points; 95% CI: -8.2, 0.6) and visual motor abilities (-5.3 points; 95% CI: -11.0, 0.4). Cross-sectional associations of major roadway proximity and cognition at mid-childhood were weaker. Prenatal and childhood exposure to traffic density and PM2.5 did not appear to be associated with poorer cognitive performance. Third-trimester and childhood BC exposures were associated with lower verbal IQ in minimally adjusted models; but after adjustment for socioeconomic covariates, associations were attenuated or reversed.

conclusionsResidential proximity to major roadways during gestation and early life may affect cognitive development. Influences of pollutants and socioeconomic conditions on cognition may be difficult to disentangle.

Indexed as

Environmental ExposureAdolescentAdultAir PollutantsCarbonChildCognitionCross-Sectional StudiesEnvironmental MonitoringFemaleHumansMaleMassachusettsParticulate MatterPregnancyPrenatal Exposure Delayed EffectsAir PollutantsCarbonParticulate MatterVehicle Emissions

Identifiers

PMID25839914
PMCPMC4590752

What OpenQuestion holds

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LicenceCC0
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.