Evidence map›Paper›PMID 25839730›Full record

ArticleAIDS research and human retroviruses2015

Differences in Evolution of HIV-1 Subtype C Reverse Transcriptase Between Children and Adults Likely Explained by Maturity of Cytotoxic T-Lymphocyte Responses.

Shanmugam Saravanan, Selvamurthi Gomathi, Bagavathi Kausalya, Jayaseelan Boobalan, Kailapuri G Murugavel, Pachamuthu Balakrishnan, Sarvode N Mothi, Sunil S Solomon, Nagalingeswaran Kumarasamy, Poongulali Selvamuthu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS research and human retroviruses, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shanmugam Saravanan1YRG CARE, Chennai, India.
Selvamurthi Gomathi1YRG CARE, Chennai, India.
Bagavathi Kausalya1YRG CARE, Chennai, India.
Jayaseelan Boobalan1YRG CARE, Chennai, India.
Kailapuri G Murugavel1YRG CARE, Chennai, India.
Pachamuthu Balakrishnan1YRG CARE, Chennai, India.
Sarvode N Mothi2Asha Kirana Hospital, Mysore, India.
Sunil S Solomon1YRG CARE, Chennai, India.
Nagalingeswaran Kumarasamy1YRG CARE, Chennai, India.
Poongulali Selvamuthu1YRG CARE, Chennai, India.
Suniti Solomon1YRG CARE, Chennai, India.
Davey M Smith4University of California San Diego, La Jolla, California.

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI David Mitchell Smith · 1994 to 2026
$78.4M
STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAVID J MOORE · 2001 to 2026
$50.4M
Molecular Epidemiology for HIV Prevention for Drug Users and Other Risk Groups DP1DA034978 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SMITH, DAVID MITCHELL · 2012 to 2016
$4.1M
Mentoring Translational Research in HIVK24AI100665 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SMITH, DAVID MITCHELL · 2012 to 2021
$1.5M
Combined Testing to Identify Virologic Failure and HIV-1 Drug ResistanceR03EB015365 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SMITH, DAVID MITCHELL · 2014 to 2015
$233k
NIAID NIH HHS AI036214NIAID NIH HHS AI100665NIBIB NIH HHS EB015365NIDA NIH HHS DA034978NIMH NIH HHS MH062512
6 · The paper itself

Abstract

In this study HIV-1 subtype C-infected adults demonstrated higher purifying selection on their viral populations in reverse transcriptase (RT) than infected children. This difference is likely explained by more mature cytotoxic T-lymphocyte responses in adults, which may have implications for the development of drug resistance in the RT region.

Indexed as

Evolution, MolecularGenetic VariationAdultChildFemaleGenotypeHIV-1HIV Reverse TranscriptaseHumansMaleMiddle AgedMolecular Sequence DataSelection, GeneticSequence Analysis, DNAT-Lymphocytes, CytotoxicHIV Reverse Transcriptasereverse transcriptase, Human immunodeficiency virus 1

Identifiers

PMID25839730
PMCPMC4458742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.