Evidence map›Paper›PMID 25839231›Full record

ArticleThe Journal of biological chemistry2015

Thrombospondin-1 (TSP1)-producing B cells restore antigen (Ag)-specific immune tolerance in an allergic environment.

Gui Yang, Xiao-Rui Geng, Zhi-Qiang Liu, Jiang-Qi Liu, Xiao-Yu Liu, Ling-Zhi Xu, Huan-Ping Zhang, Ying-Xue Sun, Zhi-Gang Liu, Ping-Chang Yang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Review
  3. Emerging functions of thrombospondin-1 in immunity.Seminars in cell & developmental biology · 2024
    Review
  4. Tolerating CD47.Clinical and translational medicine · 2024
    Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Thrombospondin-1 regulation of latent TGF-β activation: A therapeutic target for fibrotic disease.Matrix biology : journal of the International Society for Matrix Biology · 2018
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Innate and adaptive dendritic cell responses to immunotherapy.Current opinion in allergy and clinical immunology · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Gui YangFrom the ENT Institute of Shenzhen University, Shenzhen Key Laboratory of Allergy and Immunology, Shenzhen University School of Medicine, and State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen University, Shenzhen 518060, China, the Brain Body Institute, McMaster University, Hamilton, Ontario L8N 4A6, Canada, and Longgang Central Hospital, Shenzhen 518116, China.
Xiao-Rui GengFrom the ENT Institute of Shenzhen University, Shenzhen Key Laboratory of Allergy and Immunology, Shenzhen University School of Medicine, and State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen University, Shenzhen 518060, China, the Brain Body Institute, McMaster University, Hamilton, Ontario L8N 4A6, Canada, and Longgang Central Hospital, Shenzhen 518116, China.
Zhi-Qiang LiuFrom the ENT Institute of Shenzhen University, Shenzhen Key Laboratory of Allergy and Immunology, Shenzhen University School of Medicine, and State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen University, Shenzhen 518060, China, the Brain Body Institute, McMaster University, Hamilton, Ontario L8N 4A6, Canada, and Longgang Central Hospital, Shenzhen 518116, China.
Jiang-Qi LiuFrom the ENT Institute of Shenzhen University, Shenzhen Key Laboratory of Allergy and Immunology, Shenzhen University School of Medicine, and State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen University, Shenzhen 518060, China, the Brain Body Institute, McMaster University, Hamilton, Ontario L8N 4A6, Canada, and Longgang Central Hospital, Shenzhen 518116, China.
Xiao-Yu LiuFrom the ENT Institute of Shenzhen University, Shenzhen Key Laboratory of Allergy and Immunology, Shenzhen University School of Medicine, and State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen University, Shenzhen 518060, China.
Ling-Zhi XuFrom the ENT Institute of Shenzhen University, Shenzhen Key Laboratory of Allergy and Immunology, Shenzhen University School of Medicine, and State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen University, Shenzhen 518060, China.
Huan-Ping Zhangthe Brain Body Institute, McMaster University, Hamilton, Ontario L8N 4A6, Canada, and.
Ying-Xue Sunthe Brain Body Institute, McMaster University, Hamilton, Ontario L8N 4A6, Canada, and.
Zhi-Gang LiuFrom the ENT Institute of Shenzhen University, Shenzhen Key Laboratory of Allergy and Immunology, Shenzhen University School of Medicine, and State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen University, Shenzhen 518060, China, lzg@szu.edu.cn.
Ping-Chang YangFrom the ENT Institute of Shenzhen University, Shenzhen Key Laboratory of Allergy and Immunology, Shenzhen University School of Medicine, and State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen University, Shenzhen 518060, China, the Brain Body Institute, McMaster University, Hamilton, Ontario L8N 4A6, Canada, and pcy2356@szu.edu.cn.
Shenzhen University · CNMcMaster University · CALonggang Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Restoration of the antigen (Ag)-specific immune tolerance in an allergic environment is refractory. B cells are involved in immune regulation. Whether B cells facilitate the generation of Ag-specific immune tolerance in an allergic environment requires further investigation. This paper aims to elucidate the mechanism by which B cells restore the Ag-specific immune tolerance in an allergic environment. In this study, a B cell-deficient mouse model was created by injecting an anti-CD20 antibody. The frequency of tolerogenic dendritic cell (TolDC) was assessed by flow cytometry. The levels of cytokines were determined by enzyme-linked immunosorbent assay. The expression of thrombospondin-1 (TSP1) was assessed by quantitative real-time RT-PCR, Western blotting, and methylation-specific PCR. The results showed that B cells were required in the generation of the TGF-β-producing TolDCs in mice. B cell-derived TSP1 converted the latent TGF-β to the active TGF-β in DCs, which generated TGF-β-producing TolDCs. Exposure to IL-13 inhibited the expression of TSP1 in B cells by enhancing the TSP1 gene DNA methylation. Treating food allergy mice with Ag-specific immunotherapy and IL-13 antagonists restored the generation of TolDCs and enhanced the effect of specific immunotherapy. In conclusion, B cells play a critical role in the restoration of specific immune tolerance in an allergic environment. Blocking IL-13 in an allergic environment facilitated the generation of TolDCs and enhanced the therapeutic effect of immunotherapy.

Indexed as

Desensitization, ImmunologicAnimalsB-LymphocytesDendritic CellsDNA MethylationFood HypersensitivityImmune ToleranceInterleukin-13MaleMiceThrombospondin 1Transforming Growth Factor betaInterleukin-13Thbs1 protein, mouseThrombospondin 1Transforming Growth Factor betaallergyB lymphocytecellular immune responseimmunotherapyinterleukininterleukin 13intestine

Identifiers

PMID25839231
PMCPMC4432301
OpenAlexW1961140955

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.