Evidence map›Paper›PMID 25839092›Full record

ArticleExperimental and molecular pathology2015

Temporal and spatial rearrangements of a repetitive element array on C57BL/6J mouse genome.

Kang-Hoon Lee, Lisa Yee, Debora Lim, David Greenhalgh, Kiho Cho

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and molecular pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kang-Hoon LeeDepartment of Surgery, University of California, Davis and Shriners Hospitals for Children Northern California, Sacramento, CA 95817, USA.
Lisa YeeDepartment of Surgery, University of California, Davis and Shriners Hospitals for Children Northern California, Sacramento, CA 95817, USA.
Debora LimDepartment of Surgery, University of California, Davis and Shriners Hospitals for Children Northern California, Sacramento, CA 95817, USA.
David GreenhalghDepartment of Surgery, University of California, Davis and Shriners Hospitals for Children Northern California, Sacramento, CA 95817, USA.
Kiho ChoDepartment of Surgery, University of California, Davis and Shriners Hospitals for Children Northern California, Sacramento, CA 95817, USA. Electronic address: kcho@ucdavis.edu.
Shriners Hospitals for Children - Northern California · USUniversity of California, Davis · US

Funding

Endogenous Retroviruses and Gene Regulation After InjuryR01GM071360 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHO, KIHO · 2006 to 2010
$1.1M
NIGMS NIH HHS R01 GM071360
6 · The paper itself

Abstract

Repetitive elements (REs) make up the vast majority of the mammalian genomes. We identified species-specific genomic libraries of RE arrays. The non-random configurations of RE arrays suggest their functions. We tested whether RE arrays undergo age- and tissue/cell-specific rearrangements. An RE array of C57BL/6J mice, containing tandem repeats of a mosaic of transposable REs, was selected to examine rearrangements in different ages and tissues. There were marked changes in the array configuration in the genomes of the skin and brain in all mice of six weeks and older, whereas the heart and liver had alterations at 29weeks. The temporal variations were confirmed by identifying putative rearrangement junctions. Temporal and spatial rearrangements of certain RE arrays may contribute to the acquired characteristics of the genome information system.

Indexed as

GenomeRepetitive Sequences, Nucleic AcidAnimalsBase SequenceBrainMiceMice, Inbred C57BLMolecular Sequence DataOrgan SpecificityPolymorphism, GeneticSkinSpecies SpecificityAcquired genome characteristicsDynamic genomeFour-dimensional genome unitRE array(CHR7.32)Spatial rearrangementTemporal rearrangement

Identifiers

PMID25839092
PMCPMC4433582
OpenAlexW2070145488

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.