Evidence map›Paper›PMID 25839058›Full record

ArticleAustin journal of nutrition and food sciences2014

Role of Cellular Magnesium in Human Diseases.

Samantha Long, Andrea Mp Romani

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Austin journal of nutrition and food sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Magnesium (MgCurrent pharmaceutical design · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. 'Magnesium'-the master cation-as a drug-possibilities and evidences.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2021
    Review
  16. Ratio of Serum Calcium to Magnesium Levels on Pregnancy with and without Preeclampsia.Medical science monitor : international medical journal of experimental and clinical research · 2021
    Observational
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Samantha LongDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, USA.
Andrea Mp RomaniDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, USA.
Case Western Reserve University · US

Funding

Mg2+ homeostasis in liver cells treated with EtOHR01AA011593 · NIAAA · CASE WESTERN RESERVE UNIVERSITY · PI ROMANI, ANDREA M · 2000 to 2009
$1.5M
NIAAA NIH HHS R01 AA011593
6 · The paper itself

Abstract

Magnesium is required for many of the major organs to function and plays a crucial role in human and mammalian physiology. Magnesium is essential for the structure of bones and teeth, acts as a cofactor for more than 300 enzymes in the body, including binding to ATP for kinase reactions, and affects permeability of excitable membranes and neuromuscular transmission. Despite these essential roles, much is still unknown about magnesium physiology and homeostasis. Currently, nutritionists believe that the general population intakes insufficient magnesium daily through the diet. The effects of magnesium deficiency are, for the most part undetected, and simple, widespread assessments of magnesium intake remain unavailable for humans. Many of the patients admitted to hospitals or medical care facilities are unaware of their low magnesium levels. Moreover, because magnesium is predominantly an intracellular cation (>99%), serum magnesium levels remain a poor predictor of tissue magnesium content and availability. This review will discuss the effects of magnesium deficiency in various pathologies affecting the human population. The underlying causes for magnesium depletion in major physiological systems will be examined along with the involved signaling pathways and the main roles of magnesium homeostasis. Where possible (e.g. alcoholism), the implications of administering supplemental magnesium will be discussed. Ultimately, this review will advocate for the necessity of identifying easy and reproducible methods to assess serum and cellular magnesium levels and to identify magnesium deficiency in order to alleviate related pathological conditions.

Indexed as

AlcoholismBonesCardiovascular systemDiabetesEndocrine systemMagnesium homeostasisRenal systemReproductive biology

Identifiers

PMID25839058
PMCPMC4379450
OpenAlexW1923670190

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.