ArticleJournal of obesity2015
Obesity and metabolic phenotypes (metabolically healthy and unhealthy variants) are significantly associated with prevalence of elevated C-reactive protein and hepatic steatosis in a large healthy Brazilian population.
Article in Journal of obesity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Epidemiology, Predisposing Factors, Biomarkers, and Prevention Mechanism of Obesity: A Systematic Review.Journal of obesity · 2020Pooled it
- Asthma risk: the inseparable synergy of obesity and metabolism.BMC pulmonary medicine · 2025Article
- Systemic Inflammation Across Metabolic Obesity Phenotypes: A Cross-Sectional Study of Korean Adults Using High-Sensitivity C-Reactive Protein as a Biomarker.International journal of molecular sciences · 2024Article
- Association Between Overweight/Obesity Metabolic Phenotypes Defined by Two Criteria of Metabolic Abnormality and Cardiovascular Diseases: A Cross-Sectional Analysis in a Chinese Population.Clinical cardiology · 2024Article
- Correlation analysis of obesity phenotypes with leptin and adiponectin.Scientific reports · 2023Article
- Shared and Distinct Gut Microbial Profiles in Saudi Women with Metabolically Healthy and Unhealthy Obesity.Microorganisms · 2023Article
- Association between Metabolic Obesity Phenotypes and the Burden of Hospitalized Postmenopausal Patients Concomitant with Osteoporosis: A Retrospective Cohort Study Based on the National Readmission Database.Journal of clinical medicine · 2023Article
- The short- and long-term readmission of four major categories of digestive system cancers: does obesity or metabolic disorder matter?Frontiers in endocrinology · 2023Article
- Clinical Classification of Obesity and Implications for Metabolic Dysfunction-Associated Fatty Liver Disease and Treatment.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Review
- Evaluation of the predictive value of different dietary antioxidant capacity assessment methods on healthy and unhealthy phenotype in overweight and obese women.Journal of diabetes and metabolic disorders · 2022Article
- Association of Lifelines Diet Score (LLDS) and metabolically unhealthy overweight/obesity phenotypes in women: a cross-sectional study.BMC women's health · 2022Article
- Associations between Pre-Bariatric High-Sensitivity C-Reactive Protein and Post-Surgery Outcomes.Diagnostics (Basel, Switzerland) · 2021Article
- Associations of Metabolic/Obesity Phenotypes with Insulin Resistance and C-Reactive Protein: Results from the CNTR Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Why primary obesity is a disease?Journal of translational medicine · 2019Review
- Clinic, Anthropometric And Metabolic Changes In Adults With Class III Obesity Classified As Metabolically Healthy And Metabolically Unhealthy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Prevalence of different metabolic phenotypes of obesity in Iranian children and adolescents: the CASPIAN V study.Journal of diabetes and metabolic disorders · 2018Article
- Association between Liver Enzymes with Metabolically Unhealthy Obese Phenotype.Lipids in health and disease · 2018Article
- Biochemical and clinical characterization of metabolic phenotypes: a cross-sectional study from Maracaibo city, Venezuela.F1000Research · 2018Article
- Metabolically healthy obese women have longer telomere length than obese women with metabolic syndrome.PloS one · 2017Article
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12 authors.
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Abstract
backgroundAmong the obese, the so-called metabolically healthy obese (MHO) phenotype is thought to confer a lower CVD risk as compared to obesity with typical associated metabolic changes. The present study aims to determine the relationship of different subtypes of obesity with inflammatory-cardiometabolic abnormalities.
methodsWe evaluated 5,519 healthy, Brazilian subjects (43 ± 10 years, 78% males), free of known cardiovascular disease. Those with <2 metabolic risk factors (MRF) were considered metabolically healthy, and those with BMI ≥ 25 kg/m(2) and/or waist circumference meeting NCEP criteria for metabolic syndrome as overweight/obese (OW). High sensitivity C reactive protein (hsCRP) was measured to assess underlying inflammation and hepatic steatosis (HS) was determined via abdominal ultrasound.
resultsOverall, 40% of OW individuals were metabolically healthy, and 12% normal-weight had ≥2 MRF. The prevalence of elevated CRP (≥3 mg/dL) and HS in MHO versus normal weight metabolically healthy group was 22% versus 12%, and 40% versus 8% respectively (P < 0.001). Both MHO individuals and metabolically unhealthy normal weight (MUNW) phenotypes were associated with elevated hsCRP and HS.
conclusionOur study suggests that MHO and MUNW phenotypes may not be benign and physicians should strive to treat individuals in these subgroups to reverse these conditions.
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