ArticleJournal of the National Cancer Institute2015
A rare truncating BRCA2 variant and genetic susceptibility to upper aerodigestive tract cancer.
Open access · bronzeAbstract read
In one paragraph
Article in Journal of the National Cancer Institute, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
12.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers.PLoS genetics · 2021Pooled it
- Rare variants in BRCA2 and CHEK2 are associated with the risk of urinary tract cancers.Scientific reports · 2016Pooled it
- Cross-ancestral GWAS identifies 29 variants across head and neck cancer subsites.Nature communications · 2025Article
- BRCA2 Germline Mutations Identify Gastric Cancers Responsive to PARP Inhibitors.Cancer research · 2023Article
- A Single nucleotide polymorphism in the ALDH2 gene modifies the risk of esophageal squamous cell carcinoma in BRCA2 p.K3326* carriers.PloS one · 2023Article
- BRCA2 mutation in advanced lung squamous cell carcinoma treated with Olaparib and a PD-1 inhibitor: a case report.Frontiers in oncology · 2023Article
- Functional studies of lung cancer GWAS beyond association.Human molecular genetics · 2022Review
- Article
- Rare deleterious germline variants and risk of lung cancer.NPJ precision oncology · 2021Article
- K3326X and Other C-Terminal BRCA2 Variants Implicated in Hereditary Cancer Syndromes: A Review.Cancers · 2021Review
- Germline BRCA2 Truncating Mutation in Familial Esophageal Squamous Cell Carcinoma: A Case Controlled Study in China.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Treatment of Pediatric Glioblastoma with Combination Olaparib and Temozolomide Demonstrates 2-Year Durable Response.The oncologist · 2020Article
- Rare Variants in Known Susceptibility Loci and Their Contribution to Risk of Lung Cancer.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2018Article
- Association of BRCA2 K3326* With Small Cell Lung Cancer and Squamous Cell Cancer of the Skin.Journal of the National Cancer Institute · 2018Article
- A novel BRCA2 mutation in prostate cancer sensitive to combined radiotherapy and androgen deprivation therapy.Cancer biology & therapy · 2018Article
- Incidental and clinically actionable genetic variants in 1005 whole exomes and genomes from Qatar.Molecular genetics and genomics : MGG · 2018Article
- International cancer seminars: a focus on esophageal squamous cell carcinoma.Annals of oncology : official journal of the European Society for Medical Oncology · 2017Review
- Monoallelic characteristic-bearing heterozygous L1053X in BRCA2 gene among Sudanese women with breast cancer.BMC medical genetics · 2017Article
- Differential analysis of mutations in the Jewish population and their implications for diseases.Genetics research · 2017Article
- BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers.Journal of the National Cancer Institute · 2016Article
Corrections and comments
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Authors and funding
48 authors at 17 institutions in 17 countries.
Manon Delahaye-Sourdeix: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Devasena Anantharaman: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Maria N Timofeeva: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Valérie Gaborieau: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Amélie Chabrier: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Maxime P Vallée: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Pagona Lagiou: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Ivana Holcátová: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Lorenzo Richiardi: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Kristina Kjaerheim: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Antonio Agudo: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Xavier Castellsagué: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Tatiana V Macfarlane: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Luigi Barzan: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Cristina Canova: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Nalin S Thakker: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
David I Conway: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Ariana Znaor: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Claire M Healy: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Wolfgang Ahrens: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
David Zaridze: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Neonilia Szeszenia-Dabrowska: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Jolanta Lissowska: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Eleonora Fabianova: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Ioan Nicolae Mates: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Vladimir Bencko: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Lenka Foretova: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Vladimir Janout: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Maria Paula Curado: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Sergio Koifman: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Ana Menezes: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Victor Wünsch-Filho: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
José Eluf-Neto: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Paolo Boffetta: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Leticia Fernández Garrote: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Jerry Polesel: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Marcin Lener: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Ewa Jaworowska: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Jan Lubiński: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Stefania Boccia: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Thangarajan Rajkumar: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Tanuja A Samant: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Manoj B Mahimkar: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Keitaro Matsuo: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Silvia Franceschi: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Graham Byrnes: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Paul Brennan: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
James D McKay: Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
Cancer Genetics (United States) · USCentre International de Recherche sur le Cancer · FRCentro di Riferimento Oncologico · ITGenetic Alliance UK (United Kingdom) · GBUniversity of Madras · INBiology of Infection · FRCancer Registry of Norway · NOFundação Oswaldo Cruz · BRInstituto Nacional de Salud · PEMasaryk Memorial Cancer Institute · CZNational and Kapodistrian University of Athens · GRPomeranian Medical University · PLTrinity College Dublin · IEUniversidade Federal de Pelotas · BRUniversità Cattolica del Sacro Cuore · ITUniversity of Edinburgh · GBUniversity of Padua · IT
Funding
GENETICS OF TOBACCO AND ALCOHOL RELATED CANCERSR01CA092039 · NCI · INTERNATIONAL AGENCY FOR RES ON CANCER · PI BRENNAN, PAUL JOSEPH · 2003 to 2010
$3.6MInvestigation of genetic variation in the alcohol metabolism genes and other keyR03DE020116 · NIDCR · INTERNATIONAL AGENCY FOR RES ON CANCER · PI MCKAY, JAMES DOWLING · 2010 to 2011
$175kNCI NIH HHS R01CA092039 05/05S1NIDCR NIH HHS 1R03DE020116World Health Organization 001
Abstract
Deleterious BRCA2 genetic variants markedly increase risk of developing breast cancer. A rare truncating BRCA2 genetic variant, rs11571833 (K3326X), has been associated with a 2.5-fold risk of lung squamous cell carcinoma but only a modest 26% increase in breast cancer risk. We analyzed the association between BRCA2 SNP rs11571833 and upper aerodigestive tract (UADT) cancer risk with multivariable unconditional logistic regression adjusted by sex and combinations of study and country for 5942 UADT squamous cell carcinoma case patients and 8086 control patients from nine different studies. All statistical tests were two-sided. rs11571833 was associated with UADT cancers (odds ratio = 2.53, 95% confidence interval = 1.89 to 3.38, P = 3x10(-10)) and was present in European, Latin American, and Indian populations but extremely rare in Japanese populations. The association appeared more apparent in smokers (current or former) compared with never smokers (P het = .026). A robust association between a truncating BRCA2 variant and UADT cancer risk suggests that treatment strategies orientated towards BRCA2 mutations may warrant further investigation in UADT tumors.
Indexed as
Polymorphism, Single NucleotideAdultAgedAlcohol DrinkingBRCA2 ProteinCarcinoma, Squamous CellCase-Control StudiesFemaleGenetic Predisposition to DiseaseHead and Neck NeoplasmsHumansLogistic ModelsMaleMiddle AgedOdds RatioRisk AssessmentBRCA2 ProteinBRCA2 protein, human
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