ArticleArteriosclerosis, thrombosis, and vascular biology2015
Lean and Obese Coronary Perivascular Adipose Tissue Impairs Vasodilation via Differential Inhibition of Vascular Smooth Muscle K+ Channels.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 42 citations in OpenAlex.
- Potassium channels in vascular smooth muscle cells.Physiological reviews · 2026Review
- Obesity-Associated Adiposomes Promote Vascular Smooth Muscle Cell Hypercontractility.Comprehensive Physiology · 2025Article
- Regional and systemic adipose mass and peripheral conduit artery function.Diabetes research and clinical practice · 2025Article
- Innervation of adipocytes is limited in mouse perivascular adipose tissue.American journal of physiology. Heart and circulatory physiology · 2024Article
- Perivascular Adipose Tissue and Uterine Artery Adaptations to Pregnancy.Microcirculation (New York, N.Y. : 1994) · 2024Review
- Visceral adipose of obese mice inhibits endothelial inwardly rectifying KAmerican journal of physiology. Cell physiology · 2024Article
- Review
- Endothelium-Derived Relaxing Factors and Endothelial Function: A Systematic Review.Biomedicines · 2022Review
- Cyclooxygenase-dependent mechanisms mediate in part the anti-dilatory effects of perivascular adipose tissue in uterine arteries from pregnant rats.Pharmacological research · 2021Article
- Guidelines for the measurement of vascular function and structure in isolated arteries and veins.American journal of physiology. Heart and circulatory physiology · 2021Review
- Phenotypic Changes in T Cell and Macrophage Subtypes in Perivascular Adipose Tissues Precede High-Fat Diet-Induced Hypertension.Frontiers in physiology · 2021Article
- Naïve, Regulatory, Activated, and Memory Immune Cells Co-exist in PVATs That Are Comparable in Density to Non-PVAT Fats in Health.Frontiers in physiology · 2020Article
- Perivascular Adipose Tissue as an Indication, Contributor to, and Therapeutic Target for Atherosclerosis.Frontiers in physiology · 2020Review
- Obesity: a neuroimmunometabolic perspective.Nature reviews. Endocrinology · 2020Review
- Aldosterone impairs coronary adenosine-mediated vasodilation via reduced functional expression of CaAmerican journal of physiology. Heart and circulatory physiology · 2019Article
- Perivascular adipose tissue dysfunction aggravates adventitial remodeling in obese mini pigs via NLRP3 inflammasome/IL-1 signaling pathway.Acta pharmacologica Sinica · 2019Article
- Obesity and Pulmonary Hypertension.Current hypertension reports · 2018Review
- Perivascular Adipose Tissue: the Sixth Man of the Cardiovascular System.Cardiovascular drugs and therapy · 2018Review
- Cellular mechanisms underlying obesity-induced arterial stiffness.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Review
- Regulation of voltage-gated potassium channels in vascular smooth muscle during hypertension and metabolic disorders.Microcirculation (New York, N.Y. : 1994) · 2018Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe effects of coronary perivascular adipose tissue (PVAT) on vasomotor tone are influenced by an obese phenotype and are distinct from other adipose tissue depots. The purpose of this investigation was to examine the effects of lean and obese coronary PVAT on end-effector mechanisms of coronary vasodilation and to identify potential factors involved. APPROACH AND
resultsHematoxylin and eosin staining revealed similarities in coronary perivascular adipocyte size between lean and obese Ossabaw swine. Isometric tension studies of isolated coronary arteries from Ossabaw swine revealed that factors derived from lean and obese coronary PVAT attenuated vasodilation to adenosine. Lean coronary PVAT inhibited K(Ca) and KV7, but not KATP channel-mediated dilation in lean arteries. In the absence of PVAT, vasodilation to K(Ca) and KV7 channel activation was impaired in obese arteries relative to lean arteries. Obese PVAT had no effect on K(Ca) or KV7 channel-mediated dilation in obese arteries. In contrast, obese PVAT inhibited KATP channel-mediated dilation in both lean and obese arteries. The differential effects of obese versus lean PVAT were not associated with changes in either coronary KV7 or K(ATP) channel expression. Incubation with calpastatin attenuated coronary vasodilation to adenosine in lean but not in obese arteries.
conclusionsThese findings indicate that lean and obese coronary PVAT attenuates vasodilation via inhibitory effects on vascular smooth muscle K(+) channels and that alterations in specific factors such as calpastatin are capable of contributing to the initiation or progression of smooth muscle dysfunction in obesity.
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