Trial reportCirculation. Heart failure2015
Short-term intravenous sodium nitrite infusion improves cardiac and pulmonary hemodynamics in heart failure patients.
Trial report in Circulation. Heart failure, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Combination Treatment with Sodium Nitrite and Isoquercetin on Endothelial Dysfunction among Patients with CKD: A Randomized Phase 2 Pilot Trial.Clinical journal of the American Society of Nephrology : CJASN · 2020Trial
- Hemodynamic effects of IV sodium nitrite in hospitalized comatose survivors of out of hospital cardiac arrest.Resuscitation · 2018Trial
- Inorganic nitrate as a treatment for acute heart failure: a protocol for a single center, randomized, double-blind, placebo-controlled pilot and feasibility study.Journal of translational medicine · 2017Trial
- Acute hemodynamic effects of inhaled sodium nitrite in pulmonary hypertension associated with heart failure with preserved ejection fraction.JCI insight · 2016Trial
- Inhaled Sodium Nitrite Improves Rest and Exercise Hemodynamics in Heart Failure With Preserved Ejection Fraction.Circulation research · 2016Trial
- Challenging management dogma where evidence is non-existent, weak or outdated.Intensive care medicine · 2022Review
- Inorganic nitrate and nitrite supplementation fails to improve skeletal muscle mitochondrial efficiency in mice and humans.The American journal of clinical nutrition · 2020Article
- Nitrite pharmacokinetics, safety and efficacy after experimental ventricular fibrillation cardiac arrest.Nitric oxide : biology and chemistry · 2019Article
- Diastolic Ventricular Interaction in Heart Failure With Preserved Ejection Fraction.Journal of the American Heart Association · 2019Article
- Usefulness of Intravenous Sodium Nitrite During Resuscitation for the Treatment of Out-of-Hospital Cardiac Arrest.The American journal of cardiology · 2018Article
- Nitrite circumvents platelet resistance to nitric oxide in patients with heart failure preserved ejection fraction and chronic atrial fibrillation.Cardiovascular research · 2018Article
- Exercise limitations in heart failure with reduced and preserved ejection fraction.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Review
- INDIE-HFpEF (Inorganic Nitrite Delivery to Improve Exercise Capacity in Heart Failure With Preserved Ejection Fraction): Rationale and Design.Circulation. Heart failure · 2017Review
- Effect of sodium nitrite on local control of contracting skeletal muscle microvascular oxygen pressure in healthy rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Mechanistic characterization of nitrite-mediated neuroprotection after experimental cardiac arrest.Journal of neurochemistry · 2016Article
- Present and future pharmacotherapeutic agents in heart failure: an evolving paradigm.British journal of pharmacology · 2016Review
- Nitrates as a Treatment of Acute Heart Failure.Cardiac failure review · 2016Article
- Beetroot juice supplementation reduces whole body oxygen consumption but does not improve indices of mitochondrial efficiency in human skeletal muscle.The Journal of physiology · 2016Article
- Effects of nitrite infusion on skeletal muscle vascular control during exercise in rats with chronic heart failure.American journal of physiology. Heart and circulatory physiology · 2015Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundNitrite exhibits hypoxia-dependent vasodilator properties, selectively dilating capacitance vessels in healthy subjects. Unlike organic nitrates, it seems not to be subject to the development of tolerance. Currently, therapeutic options for decompensated heart failure (HF) are limited. We hypothesized that by preferentially dilating systemic capacitance and pulmonary resistance vessels although only marginally dilating resistance vessels, sodium nitrite (NaNO2) infusion would increase cardiac output but reduce systemic arterial blood pressure only modestly. We therefore undertook a first-in-human HF proof of concept/safety study, evaluating the hemodynamic effects of short-term NaNO2 infusion. METHODS AND
resultsTwenty-five patients with severe chronic HF were recruited. Eight received short-term (5 minutes) intravenous NaNO2 at 10 μg/kg/min and 17 received 50 μg/kg/min with measurement of cardiac hemodynamics. During infusion of 50 μg/kg/min, left ventricular stroke volume increased (from 43.22±21.5 to 51.84±23.6 mL; P=0.003), with marked falls in pulmonary vascular resistance (by 29%; P=0.03) and right atrial pressure (by 40%; P=0.007), but with only modest falls in mean arterial blood pressure (by 4 mm Hg; P=0.004). The increase in stroke volume correlated with the increase in estimated trans-septal gradient (=pulmonary capillary wedge pressure-right atrial pressure; r=0.67; P=0.003), suggesting relief of diastolic ventricular interaction as a contributory mechanism. Directionally similar effects were observed for the above hemodynamic parameters with 10 μg/kg/min; this was significant only for stroke volume, not for other parameters.
conclusionsThis first-in-human HF efficacy/safety study demonstrates an attractive profile during short-term systemic NaNO2 infusion that may be beneficial in decompensated HF and warrants further evaluation with longer infusion regimens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.