ArticleProceedings of the National Academy of Sciences of the United States of America2015
PLZF expression maps the early stages of ILC1 lineage development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.
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Who cites it
97 citing papers in PubMed, 155 citations in OpenAlex.
- The development of innate lymphoid cells.Nature immunology · 2026Review
- Tissue-Resident ILC2s Across Organs: Heterogeneity, Niche Crosstalk, and Shared Regulatory Circuits.Immune network · 2025Review
- Single-cell multiomics identifies Tcf1 and Lef1 as key initiators of early thymic progenitor fate.Science immunology · 2025Article
- A membrane lipid signature unravels the dynamic landscape of group 1 innate lymphoid cells across the health-disease continuum.iScience · 2025Article
- NKp46 enhances type 1 innate lymphoid cell proliferation and function and anti-acute myeloid leukemia activity.Nature communications · 2025Article
- Distinct developmental pathways generate functionally distinct populations of natural killer cells.Nature immunology · 2024Article
- Eomes expression identifies the early bone marrow precursor to classical NK cells.Nature immunology · 2024Article
- Control of the Development, Distribution, and Function of Innate-Like Lymphocytes and Innate Lymphoid Cells by the Tissue Microenvironment.Advances in experimental medicine and biology · 2024Review
- Lymphoid tissue inducer cells in cancer: a potential therapeutic target.Molecular and cellular biochemistry · 2023Review
- Article
- T cells in health and disease.Signal transduction and targeted therapy · 2023Review
- Speed and navigation control of thymocyte development by the fetal T-cell gene regulatory network.Immunological reviews · 2023Review
- Early life gut microbiota sustains liver-resident natural killer cells maturation via the butyrate-IL-18 axis.Nature communications · 2023Article
- ILC1: Development, maturation, and transcriptional regulation.European journal of immunology · 2023Review
- Purification of Bone Marrow Precursors to T Cells and ILCs.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Early Development of Innate Lymphoid Cells.Methods in molecular biology (Clifton, N.J.) · 2023Review
- Identification of aceNKPs, a committed common progenitor population of the ILC1 and NK cell continuum.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Identification of the niche and mobilization mechanism for tissue-protective multipotential bone marrow ILC progenitors.Science advances · 2022Article
- Article
- Ly49E separates liver ILC1s into embryo-derived and postnatal subsets with different functions.The Journal of experimental medicine · 2022Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Among the variety of tissue-resident NK-like populations recently distinguished from recirculating classical NK (cNK) cells, liver innate lymphoid cells (ILC) type 1 (ILC1s) have been shown to represent a distinct lineage that originates from a novel promyelocytic leukaemia zinc finger (PLZF)-expressing ILC precursor (ILCP) strictly committed to the ILC1, ILC2, and ILC3 lineages. Here, using PLZF-reporter mice and cell transfer assays, we studied the developmental progression of ILC1s and demonstrated substantial overlap with stages previously ascribed to the cNK lineage, including pre-pro-NK, pre-NK precursor (pre-NKP), refined NKP (rNKP), and immature NK (iNK). Although they originated from different precursors, the ILC1 and cNK lineages followed a parallel progression at early stages and diverged later at the iNK stage, with a striking predominance of ILC1s over cNKs early in ontogeny. Although a limited set of ILC1 genes depended on PLZF for expression, characteristically including Il7r, most of these genes were also differentially expressed between ILC1s and cNKs, indicating that PLZF together with other, yet to be defined, factors contribute to the divergence between these lineages.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.