ArticleThe Journal of infectious diseases2015
Analysis of Erythrocyte Invasion Mechanisms of Plasmodium falciparum Clinical Isolates Across 3 Malaria-Endemic Areas in Ghana.
Article in The Journal of infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Malaria exposure remodels the plasma proteome of Ghanaian children.BMC infectious diseases · 2025Article
- Gossypol is a natural product with good antimalarial activity against Plasmodium falciparum clinical isolates.Scientific reports · 2025Article
- Transcriptome analysis reveals molecular targets of erythrocyte invasion phenotype diversity in naturalFrontiers in parasitology · 2024Article
- Recent increase in low complexity polygenomic infections and sialic acid-independent invasion pathways in Plasmodium falciparum from Western Gambia.Parasites & vectors · 2023Article
- Patterns of Heterochromatin Transitions Linked to Changes in the Expression of Plasmodium falciparum Clonally Variant Genes.Microbiology spectrum · 2023Article
- Performance of SNP barcodes to determine genetic diversity and population structure ofFrontiers in genetics · 2023Article
- Phenotypic characterization of GhanaianFrontiers in immunology · 2022Article
- Localization and function of aExperimental biology and medicine (Maywood, N.J.) · 2021Article
- Genome-Wide Scans for GhanaianFrontiers in cellular and infection microbiology · 2021Article
- Comparative analysis of asexual and sexual stage Plasmodium falciparum development in different red blood cell types.Malaria journal · 2020Article
- Investigating a Plasmodium falciparum erythrocyte invasion phenotype switch at the whole transcriptome level.Scientific reports · 2020Article
- Molecular Characterization and Immuno-Reactivity Patterns of a NovelFrontiers in cellular and infection microbiology · 2020Article
- Cell trace far-red is a suitable erythrocyte dye for multi-colorExperimental biology and medicine (Maywood, N.J.) · 2020Article
- Antibody Reactivity to Merozoite Antigens in Ghanaian Adults Correlates With Growth Inhibitory Activity AgainstOpen forum infectious diseases · 2019Article
- A forward genetic screen reveals a primary role for Plasmodium falciparum Reticulocyte Binding Protein Homologue 2a and 2b in determining alternative erythrocyte invasion pathways.PLoS pathogens · 2018Article
- Functional Characterization of Plasmodium falciparum Surface-Related Antigen as a Potential Blood-Stage Vaccine Target.The Journal of infectious diseases · 2018Article
- An in vitro erythrocyte preference assay reveals that Plasmodium falciparum parasites prefer Type O over Type A erythrocytes.Scientific reports · 2018Article
- Plasmodium falciparum strains spontaneously switch invasion phenotype in suspension culture.Scientific reports · 2018Article
- Parasite-Related Genetic and Epigenetic Aspects and Host Factors InfluencingFrontiers in cellular and infection microbiology · 2018Review
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundPlasmodium falciparum invades human erythrocytes by using an array of ligands that interact with several receptors, including sialic acid (SA), complement receptor 1 (CR1), and basigin. We hypothesized that in malaria-endemic areas, parasites vary invasion pathways under immune pressure. Therefore, invasion mechanisms of clinical isolates collected from 3 zones of Ghana with different levels of endemicity (from lowest to highest, Accra, Navrongo, and Kintampo) were compared using standardized methods.
methodsBlood samples were collected from children aged 2-14 years in whom malaria was diagnosed, and erythrocyte invasion phenotypes were determined using the enzymes neuraminidase, chymotrypsin, and trypsin, which differentially cleave receptors from the erythrocyte surface. In addition, antibodies against CR1 and basigin were used to determine the contributions of these receptors to invasion. Gene expression levels of P. falciparum invasion ligands were also examined.
resultsThe parasites generally expressed SA-independent invasion phenotypes across the malaria-endemic areas, with parasites from Kintampo showing the highest invasion rates in neuraminidase-treated erythrocytes. CR1 was a major mediator of SA-independent invasion, while basigin was essential for both SA-dependent and SA-independent invasion mechanisms. Furthermore, expression of the basigin ligand PfRh5 was the best predictor of donor parasitemia.
conclusionsErythrocyte invasion phenotypes expressed by P. falciparum are influenced by endemicity levels, and the PfRh5-basigin pathway is a potential vaccine target.
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