ArticleeLife2015
Cis and trans RET signaling control the survival and central projection growth of rapidly adapting mechanoreceptors.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 33 citations in OpenAlex.
- A long-chain heparan sulfate capture mechanism directs paracrine GDNF-GFRα1 signalling through RET.bioRxiv : the preprint server for biology · 2026Article
- Adaptive loss of function accelerated the evolution of ancient and modern human cognition.bioRxiv : the preprint server for biology · 2026Article
- Utility of a commercial antibody against NTRK1 for western blotting and potential application to immunohistochemistry in adult mouse brain.Scientific reports · 2025Article
- Hedgehog-dependent and hedgehog-independent roles for growth arrest specific 1 in mammalian kidney morphogenesis.Development (Cambridge, England) · 2024Article
- Joint trajectory inference for single-cell genomics using deep learning with a mixture prior.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Molecular regulation of axon termination in mechanosensory neurons.Development (Cambridge, England) · 2024Review
- Pain and itch coding mechanisms of polymodal sensory neurons.Cell reports · 2023Article
- Article
- Reawakening GDNF's regenerative past in mice and humans.Regenerative therapy · 2022Article
- Article
- Improving therapeutic potential of GDNF family ligands.Cell and tissue research · 2020Review
- Plasma membrane localization of the GFL receptor components: a nexus for receptor crosstalk.Cell and tissue research · 2020Article
- RET-independent signaling by GDNF ligands and GFRα receptors.Cell and tissue research · 2020Review
- Small-molecule agonists of the RET receptor tyrosine kinase activate biased trophic signals that are influenced by the presence of GFRa1 co-receptors.The Journal of biological chemistry · 2020Article
- GDNF promotes hair formation and cutaneous wound healing by targeting bulge stem cells.NPJ Regenerative medicine · 2020Article
- CD40 forward signalling is a physiological regulator of early sensory axon growth.Development (Cambridge, England) · 2019Article
- Dual cholinergic signals regulate daily migration of hematopoietic stem cells and leukocytes.Blood · 2019Article
- Somatotopic organization of central arbors from nociceptive afferents develops independently of their intact peripheral target innervation.The Journal of comparative neurology · 2018Article
- Roof Plate-Derived Radial Glial-like Cells Support Developmental Growth of Rapidly Adapting Mechanoreceptor Ascending Axons.Cell reports · 2018Article
- Decreased ceramide underlies mitochondrial dysfunction in Charcot-Marie-Tooth 2F.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
RET can be activated in cis or trans by its co-receptors and ligands in vitro, but the physiological roles of trans signaling are unclear. Rapidly adapting (RA) mechanoreceptors in dorsal root ganglia (DRGs) express Ret and the co-receptor Gfrα2 and depend on Ret for survival and central projection growth. Here, we show that Ret and Gfrα2 null mice display comparable early central projection deficits, but Gfrα2 null RA mechanoreceptors recover later. Loss of Gfrα1, the co-receptor implicated in activating RET in trans, causes no significant central projection or cell survival deficit, but Gfrα1;Gfrα2 double nulls phenocopy Ret nulls. Finally, we demonstrate that GFRα1 produced by neighboring DRG neurons activates RET in RA mechanoreceptors. Taken together, our results suggest that trans and cis RET signaling could function in the same developmental process and that the availability of both forms of activation likely enhances but not diversifies outcomes of RET signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.