ArticlePloS one2015
Autistic-like traits in adult patients with mood disorders and schizophrenia.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- The association between autism and psychosis and the tools used to measure it: An updated systematic review and meta-analysis.The British journal of clinical psychology · 2026Pooled it
- Autistic Symptoms in Schizophrenia Spectrum Disorders: A Systematic Review and Meta-Analysis.Frontiers in psychiatry · 2019Pooled it
- Prevalence of Schizophrenia Spectrum Disorders in Average-IQ Adults with Autism Spectrum Disorders: A Meta-analysis.Journal of autism and developmental disorders · 2018Pooled it
- Developmental trajectories of social responsiveness and theory of mind in adolescent offspring at familial high-risk of schizophrenia or bipolar disorder and population-based controls-The Danish High Risk and Resilience Study, VIA 15.The British journal of clinical psychology · 2026Article
- Cognitive pathways to communicative-pragmatic dysfunction in schizophrenia: The role of autistic symptoms.Schizophrenia research. Cognition · 2026Article
- Autistic Trait Profiles Across Mood and Psychotic Spectrum Disorders: A Transdiagnostic Outpatient Study.Journal of clinical medicine · 2026Article
- Reduced intra-frontal functional connectivity during a verbal fluency task in depressed individuals with autistic traits: an fNIRS study.Frontiers in human neuroscience · 2026Article
- Autistic traits in unaffected first-degree relatives of individuals with schizophrenia and bipolar disorder: implications for shared familial neurodevelopmental vulnerability.Frontiers in psychiatry · 2026Article
- Understanding the interplay of autistic traits, depression and suicidal ideation in adolescents with major depressive disorder.Scientific reports · 2025Article
- Autism traits and mental well-being: the mediating role of social camouflaging and the moderating role of social exclusion and public stigma.Scientific reports · 2025Article
- Autistic Traits in Schizophrenia: Immune Mechanisms and Inflammatory Biomarkers.International journal of molecular sciences · 2025Review
- Mental Health Correlates of Autistic and ADHD Traits in Secondary School Students.Brain sciences · 2025Article
- Subthreshold Autism and ADHD: A Brief Narrative Review for Frontline Clinicians.Pediatric reports · 2025Review
- Autistic Traits Are Associated with Suicidal Thoughts and Behaviors Among Patients with Borderline Personality Disorder.Brain sciences · 2025Article
- Altered Rhythmicity, Depressive Ruminative Thinking and Suicidal Ideation as Possible Correlates of an Unrecognized Autism Spectrum in Patients with Borderline Personality Disorder.Brain sciences · 2024Article
- Prevalence of autistic traits and their relationships with other psychopathological domains in young adults seeking psychiatric attention: a cluster analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Major Depressive Disorder with Catatonia: A Phenotype Related to Autistic Traits and High Suicidality.Journal of clinical medicine · 2024Article
- Discrepancy between Clinician-rated and Self-reported Depression Severity is Associated with Adverse Childhood Experience, Autistic-like Traits, and Coping Styles in Mood Disorders.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023Article
- A comprehensive perspective of autistic traits and catatonic symptoms in a patient with Fronto-Temporal Dementia and Bipolar Disorder: a case report.BMC psychiatry · 2023Article
- The Cerebellum Gets Social: Evidence from an Exploratory Study of Cerebellar, Neurodevelopmental, and Psychiatric Disorders.Biomedicines · 2023Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism spectrum disorder often co-occurs with other psychiatric disorders. Although a high prevalence of autistic-like traits/symptoms has been identified in the pediatric psychiatric population of normal intelligence, there are no reports from adult psychiatric population. This study examined whether there is a greater prevalence of autistic-like traits/symptoms in patients with adult-onset psychiatric disorders such as major depressive disorder (MDD), bipolar disorder, or schizophrenia, and whether such an association is independent of symptom severity. The subjects were 290 adults of normal intelligence between 25 and 59 years of age (MDD, n=125; bipolar disorder, n=56; schizophrenia, n=44; healthy controls, n=65). Autistic-like traits/symptoms were measured using the Social Responsiveness Scale for Adults. Symptom severity was measured using the Positive and Negative Symptoms Scale, the Hamilton Depression Rating Scale, and/or the Young Mania Rating Scale. Almost half of the clinical subjects, except those with remitted MDD, exhibited autistic-like traits/symptoms at levels typical for sub-threshold or threshold autism spectrum disorder. Furthermore, the proportion of psychiatric patients that demonstrated high autistic-like traits/symptoms was significantly greater than that of healthy controls, and not different between that of remitted or unremitted subjects with bipolar disorder or schizophrenia. On the other hand, remitted subjects with MDD did not differ from healthy controls with regard to the prevalence or degree of high autistic-like traits/symptoms. A substantial proportion of adults with bipolar disorder and schizophrenia showed high autistic-like traits/symptoms independent of symptom severity, suggesting a shared pathophysiology among autism spectrum disorder and these psychiatric disorders. Conversely, autistic-like traits among subjects with MDD were associated with the depressive symptom severity. These findings suggest the importance of evaluating autistic-like traits/symptoms underlying adult-onset psychiatric disorders for the best-suited treatment. Further studies with a prospective design and larger samples are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.