ArticleCerebral cortex (New York, N.Y. : 1991)2015
Beyond Columnar Organization: Cell Type- and Target Layer-Specific Principles of Horizontal Axon Projection Patterns in Rat Vibrissal Cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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67 citing papers in PubMed, 114 citations in OpenAlex.
- Article
- An in silico framework for dissecting the mechanistic origins of in vivo recorded neuronal activity.PLoS computational biology · 2026Article
- Controlling Spatio-Temporal Sequences of Neural Activity by Local Synaptic Changes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Cell-type-specific parallel pathways in the canonical cortical microcircuit.bioRxiv : the preprint server for biology · 2026Article
- Temperature robustness of the timing network within songbird premotor nucleus HVC.Journal of computational neuroscience · 2026Article
- Human Neocortical Glutamatergic Neurons Revealed Through Multimodal Profiling.bioRxiv : the preprint server for biology · 2026Article
- Thalamus enables active dendritic coupling of inputs arriving at different cortical layers.Nature communications · 2025Article
- Dynamic recruitment of PV interneurons in the somatosensory cortex induced by experience dependent plasticity.bioRxiv : the preprint server for biology · 2025Article
- Learning to combine top-down context and feed-forward representations under ambiguity with apical and basal dendrites.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Information transfer and recovery for the sense of touch.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Circuits and mechanisms for TMS-induced corticospinal waves: Connecting sensitivity analysis to the network graph.PLoS computational biology · 2024Article
- A strong direct link from the layer 3/4 border to layer 6 of cat primary visual cortex.Brain structure & function · 2024Article
- Cell-type-specific inhibitory circuitry from a connectomic census of mouse visual cortex.bioRxiv : the preprint server for biology · 2024Article
- How deep is the brain? The shallow brain hypothesis.Nature reviews. Neuroscience · 2023Review
- Layer 1 of somatosensory cortex: an important site for input to a tiny cortical compartment.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Simulation-based inference for efficient identification of generative models in computational connectomics.PLoS computational biology · 2023Article
- Velocity of conduction between columns and layers in barrel cortex reported by parvalbumin interneurons.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Modelling novelty detection in the thalamocortical loop.PLoS computational biology · 2023Article
- Shared and divergent principles of synaptic transmission between cortical excitatory neurons in rodent and human brain.Frontiers in synaptic neuroscience · 2023Review
- Connectivity concepts in neuronal network modeling.PLoS computational biology · 2022Review
7 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vertical thalamocortical afferents give rise to the elementary functional units of sensory cortex, cortical columns. Principles that underlie communication between columns remain however unknown. Here we unravel these by reconstructing in vivo-labeled neurons from all excitatory cell types in the vibrissal part of rat primary somatosensory cortex (vS1). Integrating the morphologies into an exact 3D model of vS1 revealed that the majority of intracortical (IC) axons project far beyond the borders of the principal column. We defined the corresponding innervation volume as the IC-unit. Deconstructing this structural cortical unit into its cell type-specific components, we found asymmetric projections that innervate columns of either the same whisker row or arc, and which subdivide vS1 into 2 orthogonal [supra-]granular and infragranular strata. We show that such organization could be most effective for encoding multi whisker inputs. Communication between columns is thus organized by multiple highly specific horizontal projection patterns, rendering IC-units as the primary structural entities for processing complex sensory stimuli.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.