ArticleDeutsches Arzteblatt international2015
Air quality, stroke, and coronary events: results of the Heinz Nixdorf Recall Study from the Ruhr Region.
Article in Deutsches Arzteblatt international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Long-term exposure to elemental carbon and disease incidence: a systematic review and meta-analysis.Environmental health : a global access science source · 2025Pooled it
- Ambient fine particulate matter of diameter ≤ 2.5 μm and risk of hemorrhagic stroke: a systemic review and meta-analysis of cohort studies.Environmental science and pollution research international · 2021Pooled it
- Association between exposure to ambient air pollution and hospital admission, incidence, and mortality of stroke: an updated systematic review and meta-analysis of more than 23 million participants.Environmental health and preventive medicine · 2021Pooled it
- Long-Term PMJournal of the American Heart Association · 2021Pooled it
- Characteristics of cohort studies of long-term exposure to PMEnvironmental science and pollution research international · 2019Pooled it
- Does residential exposure to air pollutants influence mortality and cardiovascular morbidity of older people from primary care?BMC public health · 2023Trial
- Joint effects of environmental and neighborhood socioeconomic factors on cognitive function in the Heinz Nixdorf Recall Study.Environmental research · 2025Article
- Pathways to the Brain: Impact of Fine Particulate Matter Components on the Central Nervous System.Antioxidants (Basel, Switzerland) · 2025Review
- Road traffic noise and incident ischemic heart disease, myocardial infarction, and stroke: A systematic review and meta-analysis.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- Joint associations of PMFrontiers in public health · 2025Article
- Impact of air pollution and noise exposure on cardiovascular disease incidence and mortality: A systematic review.Heliyon · 2024Review
- Health position paper and redox perspectives - Disease burden by transportation noise.Redox biology · 2024Review
- Chronic disease outcome metadata from German observational studies - public availability and FAIR principles.Scientific data · 2023Article
- Ambient Air Pollution and Stroke: An Updated Review.Stroke · 2023Review
- Association of Long-term Exposure to Particulate Air Pollution With Cardiovascular Events in California.JAMA network open · 2023Article
- Long-term air pollution exposure and incident stroke in American older adults: A national cohort study.Global epidemiology · 2022Article
- Incidence and mortality rates of strokes in Kazakhstan in 2014-2019.Scientific reports · 2022Article
- Air Pollution and Ischaemic Stroke.Annals of Indian Academy of Neurology · 2022Article
- Joint associations between neighborhood walkability, greenness, and particulate air pollution on cardiovascular mortality among adults with a history of stroke or acute myocardial infarction.Environmental epidemiology (Philadelphia, Pa.) · 2022Article
- Long-term exposure to road traffic noise and stroke incidence: a Danish Nurse Cohort study.Environmental health : a global access science source · 2021Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudies have shown that air pollution is associated with cardiopulmonary mortality, but there has been less research of the possible effect of air pollution on stroke and non-fatal coronary events. The Heinz Nixdorf Recall (HNR) study addressed the question of the effect of long-term air pollution on stroke and coronary events. Ambient acoustic noise was also considered as a risk factor.
methodsThe HNR study, initiated in 2000, is a prospective, population-based cohort study in the Ruhr region of Germany. Long-term exposure to fine-particle dust (PM10, PM2.5 and PM(2.5abs) [carbon black content]) and traffic noise at the subjects' home addresses were determined using land-use regression and dispersion models, respectively. Strokes and coronary events were ascertained from patient records by an independent end-point committee on the basis of predefined study criteria. The adjusted hazard ratio (HR) was calculated using Cox regression analysis for an increase in concentration from the 5th to the 95th percentile for each exposure.
resultsData from 4433 subjects were evaluated. The incidence of stroke was 2.03 per 1000 person-years (PY), and that of coronary events was 3.87 per 1000 PY. The highest hazard ratios for stroke were seen for PM10 (HR 2.61, 95% confidence interval [CI] 1.13-6.00) and PM2.5 (HR 3.20, 95% CI 1.26-8.09). The highest hazard ratios for coronary events were found for PM10 (HR 1.07, 95% CI 0.56-2.04) and for PM(2.5abs) (HR 1.37, 95% CI 0.80-2.36).
conclusionLong-term exposure to fine-particle dust is associated with a higher risk of stroke, regardless of the subject's exposure to noise at his or her home address. The results for coronary events are less clear, but still suggest increased risk.
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