Evidence map›Paper›PMID 25837996›Full record

ReviewOsteoarthritis and cartilage2015

The adverse effects of diabetes on osteoarthritis: update on clinical evidence and molecular mechanisms.

K B King, A K Rosenthal

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Osteoarthritis and cartilage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 4 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 4 syntheses or guidelines pooled it, 137 citations in OpenAlex.

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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

K B KingDepartment of Orthopaedics, University of Colorado School of Medicine, Aurora, CO, USA; Surgical Service, Orthopaedic Service, Eastern Colorado Health Care System, Veterans Affairs, Denver, CO, USA. Electronic address: Karen.King@UCDenver.edu.
A K RosenthalDepartment of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA; Medicine Service, Rheumatology Service, The Clement J. Zablocki Medical Center, Veterans Affairs, Milwaukee, WI, USA. Electronic address: arosenthal@mcw.edu.
Medical College of Wisconsin · USUniversity of Colorado Denver · US

Funding

Novel roles for articular cartilage vesicles in osteoarthritisI01BX000812 · VA · CLEMENT J. ZABLOCKI VA MEDICAL CENTER · PI ROSENTHAL, ANN K · 2011 to 2014
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ANK-dependent ATP efflux causes calcium pyrophosphate deposition in cartilageI01CX001143 · VA · CLEMENT J. ZABLOCKI VA MEDICAL CENTER · PI ROSENTHAL, ANN K · 2015 to 2018
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BLRD VA I01 BX000812CSRD VA I01 CX001143
6 · The paper itself

Abstract

Projected increases in the prevalence of both diabetes mellitus (DM) and osteoarthritis (OA) ensure their common co-existence. In an era of increasing attention to personalized medicine, understanding the influence of common comorbidities such as DM should result in improved care of patients with OA. In this narrative review, we summarize the literature addressing the interactions between DM and OA spanning the years from 1962 to 2014. We separated studies depending on whether they investigated clinical populations, animal models, or cells and tissues. The clinical literature addressing the influence of DM on OA and its therapeutic outcomes suggests that DM may augment the development and severity of OA and that DM increases risks associated with joint replacement surgery. The few high quality studies using animal models also support an adverse effect of DM on OA. We review strengths and weaknesses of the common rodent models of DM. The heterogeneous literature derived from studies of articular cells and tissues also supports the existence of biochemical and biomechanical changes in articular tissues in DM, and begins to characterize molecular mechanisms activated in diabetic-like environs which may contribute to OA. Increasing evidence from the clinic and the laboratory supports an adverse effect of DM on the development, severity, and therapeutic outcomes for OA. To understand the mechanisms through which DM contributes to OA, further studies are clearly necessary. Future studies of DM-influenced mechanisms may shed light on general mechanisms of OA pathogenesis and result in more specific and effective therapies for all OA patients.

Indexed as

AnimalsArthritis, ExperimentalDiabetes Mellitus, Type 2Evidence-Based MedicineHumansHyperglycemiaOsteoarthritisDiabetesHyperglycemiaOsteoarthritis

Identifiers

PMID25837996
PMCPMC5530368
OpenAlexW2051809602

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.