Evidence map›Paper›PMID 25837872›Full record

ArticleNature structural & molecular biology2015

How to open a proton pore-more than S4?

Marcel P Goldschen-Ohm, Baron Chanda

Abstract readComment
PubMed Publisher
In one paragraph

Article in Nature structural & molecular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Marcel P Goldschen-OhmDepartments of Neuroscience and Biomolecular Chemistry, University of Wisconsin, Madison, Wisconsin, USA.
Baron ChandaDepartments of Neuroscience and Biomolecular Chemistry, University of Wisconsin, Madison, Wisconsin, USA.ORCID 0000000349547034
University of Wisconsin System · US

Funding

Structural basis of modulation of Na+ channels by local anestheticsR01GM084140 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI CHANDA, BARON · 2008 to 2016
$3.3M
Thermodynamics and Energetics of voltage-gated ion channelsR01NS081293 · NINDS · WASHINGTON UNIVERSITY · PI CHANDA, BARON · 2012 to 2019
$2.9M
NIGMS NIH HHS R01 GM084140NINDS NIH HHS R01 NS081293
6 · The paper itself

Abstract

Pioneering studies in voltage-gated potassium channels have described movement of the voltage-sensing domain (VSD) S4 helix across the membrane electric field in molecular detail, but much less is known regarding opening of the intrinsic proton pore within VSDs of voltage-dependent proton channels. By systematically probing local kinematics, a new study reveals that movements in helix S1 correlate with pore opening and are distinct from voltage-sensing movements of the charged S4 segment.

Indexed as

Ciona intestinalisIon Channel GatingModels, MolecularAnimalsIon ChannelsIon Channels

Identifiers

PMID25837872
OpenAlexW1585330310

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.