Evidence map›Paper›PMID 25837871›Full record

ArticleNature structural & molecular biology2015

Methylation gets into rhythm with NAD(+)-SIRT1.

Luisa Tasselli, Katrin F Chua

Abstract readComment
PubMed Publisher
In one paragraph

Article in Nature structural & molecular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Genetic and epigenetic regulation of human aging and longevity.Biochimica et biophysica acta. Molecular basis of disease · 2019
    Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Luisa TasselliDepartment of Medicine, Stanford University School of Medicine, Stanford, California, USA, and the Geriatric Research, Education and Clinical Center, Palo Alto Veterans Affairs Health Care System Health Care System, Palo Alto, California, USA.
Katrin F ChuaDepartment of Medicine, Stanford University School of Medicine, Stanford, California, USA, and the Geriatric Research, Education and Clinical Center, Palo Alto Veterans Affairs Health Care System Health Care System, Palo Alto, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circadian regulation of epigenetic chromatin marks drives daily transcriptional oscillation of thousands of genes and is intimately linked to cellular metabolism and bioenergetics. New work links circadian fluctuations in the activity of the SIRT1 deacetylase, a sensor of the cellular energy state, to histone-methylation changes and the circadian expression of clock-controlled genes.

Indexed as

AnimalsCircadian ClocksHistonesMyeloid-Lymphoid Leukemia ProteinNADSirtuin 1HistonesMyeloid-Lymphoid Leukemia ProteinNADSirtuin 1

Identifiers

PMID25837871

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.