ArticleJournal of affective disorders2015
Genetic and childhood trauma interaction effect on age of onset in bipolar disorder: An exploratory analysis.
Article in Journal of affective disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 55 citations in OpenAlex.
- Novel epigenetic loci identified from an epigenome-wide association study underlying brain structural changes in bipolar disorder.Psychological medicine · 2026Article
- Familial risk for bipolar disorder, childhood trauma and anxiety in youth: Behavioral approach and inhibition systems as mediators of risk.Journal of mood and anxiety disorders · 2026Article
- Multi-omics approaches for understanding gene-environment interactions in noncommunicable diseases: techniques, translation, and equity issues.Human genomics · 2025Review
- Adverse childhood experiences and 10-year depressive-symptoms trajectories among middle-aged and older adults in China: a population-based cohort study.Frontiers in public health · 2024Article
- Childhood trauma and bipolar affective disorder: Is there a linkage?Industrial psychiatry journal · 2023Review
- Polygenic Risk Scores for Bipolar Disorder: Progress and Perspectives.Neuropsychiatric disease and treatment · 2023Review
- Factors associated with onset-age in major affective disorders.Acta psychiatrica Scandinavica · 2022Article
- Functional genomic analysis delineates regulatory mechanisms of GWAS-identified bipolar disorder risk variants.Genome medicine · 2022Article
- Genetic and environment effects on structural neuroimaging endophenotype for bipolar disorder: a novel molecular approach.Translational psychiatry · 2022Article
- CADPS functional mutations in patients with bipolar disorder increase the sensitivity to stress.Molecular psychiatry · 2022Article
- Bipolar disorder: Trimodal age-at-onset distribution.Bipolar disorders · 2021Review
- Childhood Maltreatment in Bipolar Disorders.Current topics in behavioral neurosciences · 2021Article
- The Effect of Traumatic Events on the Longitudinal Course and Outcomes of Youth with Bipolar Disorder.Journal of affective disorders · 2020Article
- Effect of the Type and Number of Adverse Childhood Experiences and the Timing of Adverse Experiences on Clinical Outcomes in Individuals with Bipolar Disorder.Brain sciences · 2020Article
- The Devastating Clinical Consequences of Child Abuse and Neglect: Increased Disease Vulnerability and Poor Treatment Response in Mood Disorders.The American journal of psychiatry · 2020Review
- Gene-Environment Interactions in Psychiatry: Recent Evidence and Clinical Implications.Current psychiatry reports · 2019Review
- Clinical Practice Guidelines for Bipolar Affective Disorder (BPAD) in Children and Adolescents.Indian journal of psychiatry · 2019Article
- A Pilot Study of Reduced Olfactory Bulb Volume as a Marker of PTSD in Childhood Trauma-Exposed Adult HIV-Infected Patients.Journal of traumatic stress · 2017Article
- Data Resources for Human Functional Genomics.Current opinion in systems biology · 2017Article
- Environmental factors, life events, and trauma in the course of bipolar disorder.Psychiatry and clinical neurosciences · 2017Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
introductionThis study investigated whether early life trauma mediates genetic effects on the age at onset (AAO) of bipolar disorder.
methodData from the BiGS Consortium case samples (N=1119) were used. Childhood traumatic events were documented using the Childhood Life Events Scale (CLES). Interaction between occurrence of childhood trauma and common genetic variants throughout the genome was tested to identify single nucleotide polymorphic gene variants (SNPs) whose effects on bipolar AAO differ between individuals clearly exposed (CLES≥2) and not exposed (CLES=0) to childhood trauma.
resultsThe modal response to the CLES was 0 (N=480), but an additional 276 subjects had CLES=1, and 363 subjects reported 2 or more traumatic lifetime events. The distribution of age at onset showed a broad peak between ages 12 and 18, with the majority of subjects having onset during that period, and a significant decrease in age of onset with the number of traumatic events. No single SNP showed a statistically significant interaction with the presence of traumatic events to impact bipolar age at onset. However, SNPs in or near genes coding for calcium channel activity-related proteins (Gene Ontology: 0005262) were found to be more likely than other SNPs to show evidence of interaction using the INRICH method (p<0.001). LIMITATIONS: Retrospective ascertainment of trauma and AAO.
conclusionInteraction effects of early life trauma with genotype may have a significant effect on the development and manifestation of bipolar disorder. These effects may be mediated in part by genes involved in calcium signaling.
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