Evidence map›Paper›PMID 25837666›Full record

SynthesisOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2015

Voice outcomes following radiation versus laser microsurgery for T1 glottic carcinoma: systematic review and meta-analysis.

Matthew T Greulich, Noah P Parker, Philip Lee, Albert L Merati, Stephanie Misono

Registry-linked trialOpen access · greenAbstract readComparative StudyMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02587546 (Thulium Contact Laser in the Treatment of Tumorous and Non-tumorous Laryngotracheal Stenosis), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02587546 nacompletednot on this map

Thulium Contact Laser in the Treatment of Tumorous and Non-tumorous Laryngotracheal Stenosis

TypeinterventionalSponsorUniversity Hospital OstravaRan2015 to 2018Enrolled31ConditionsLaryngeal Carcinoma, Bilateral Vocal Cord Paresis, Subglottic StenosisArmslaryngeal carcinoma, bilateral vocal cord paralysis, subglottic stenosis
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.

  1. Voice quality after transoral COEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022
    Pooled it
  2. Trial
  3. Injection laryngoplasty during transoral laser microsurgery for early glottic cancer: a randomized controlled trial.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2022
    Trial
  4. Trial
  5. Trial
  6. Systemic therapy in the curative treatment of laryngeal cancer.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Multidimensional Voice Assessment After Management of Early Laryngeal Cancer: A Comparative Study.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. COMedicines (Basel, Switzerland) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Matthew T GreulichDepartment of Otolaryngology, University of Minnesota Medical Center, Minneapolis, Minnesota, USA.
Noah P ParkerThe Voice Clinic of Indiana, Carmel, Indiana, USA The Department of Speech and Hearing Sciences, Indiana University, Bloomington, Indiana, USA.
Philip LeeDepartment of Otolaryngology, University of Minnesota Medical Center, Minneapolis, Minnesota, USA.
Albert L MeratiDepartment of Otolaryngology, University of Washington Medical Center, Seattle, Washington, USA.
Stephanie MisonoDepartment of Otolaryngology, University of Minnesota Medical Center, Minneapolis, Minnesota, USA smisono@umn.edu.
University of Minnesota Medical Center · USIndiana University Bloomington · USUniversity of Washington Medical Center · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)KL2TR000113 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$5.4M
NCATS NIH HHS KL2 TR000113NCATS NIH HHS UL1 TR000114
6 · The paper itself

Abstract

objectiveSystematic review of literature on patient-reported voice handicap following T1 glottic squamous cell carcinoma treatment using transoral laser microsurgery or radiation therapy. DATA SOURCES: PubMed, Web of Science, and Scopus (1997-2013). REVIEW

methodsThese data sources were searched for papers reporting Voice Handicap Index (VHI) after treatment of early glottic carcinoma. Review and reference cross-checking were performed using a priori selection criteria. Study data were abstracted and publication quality categorized independently by 2 authors. Corresponding authors were contacted to maximize data for analysis. Meta-analysis was performed only with studies that included both treatment modalities, to reduce heterogeneity and maximize rigor; random effects modeling was used to pool results.

resultsEighteen publications were identified that reported VHI data following surgery and radiotherapy for T1 glottic carcinoma. No studies were randomized. When studies that reported multiple T-stages or systematic treatment selection bias were excluded, 8 retrospective cohort studies describing 362 patients were suitable for meta-analysis. Follow-up time (mean, 47 months; range, 1-298 mo) and extent of surgical excision varied across studies. Six studies showed no VHI difference between treatment arms; 2 favored radiotherapy over surgery (1 of which reported transmuscular cordectomy for all surgical patients); and none favored surgery. Meta-analysis showed no significant difference in posttreatment VHI between radiotherapy and surgery (mean difference, -5.52; 95% confidence interval, -11.40, 0.36; heterogeneity I (2) = 61%, P = .01).

conclusionVHI scores were comparable following transoral laser microsurgery and radiation therapy for T1 glottic carcinoma in the current literature, suggesting no clinically significant difference in functional voice outcomes between treatment types.

Indexed as

VoiceCarcinoma, Squamous CellGlottisHead and Neck NeoplasmsHumansLaryngeal NeoplasmsSquamous Cell Carcinoma of Head and NeckTreatment OutcomeVoice Qualityglottis/radiotherapyglottis/surgeryhumanslaryngeal neoplasmslaser therapyneoplasm stagingquality of lifevoice disordersvoice quality

Identifiers

PMID25837666
PMCPMC5560897
OpenAlexW2146424652

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.