ReviewCurrent opinion in virology2015
Computational tools for epitope vaccine design and evaluation.
Review in Current opinion in virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed.
- Deep learning in next-generation vaccine development for infectious diseases.Molecular therapy. Nucleic acids · 2025Review
- Engaging Broader Stakeholders to Accelerate Group AVaccines · 2025Review
- The dawn of biophysical representations in computational immunology.QRB discovery · 2025Review
- Respiratory Syncytial Virus Vaccine Design Using Structure-Based Machine-Learning Models.Viruses · 2024Article
- Review
- Designing an effective malaria vaccine targeting Plasmodium vivax Duffy-binding protein.Trends in parasitology · 2023Review
- Molecular Mimicry Mapping inPathogens (Basel, Switzerland) · 2023Article
- Computational approaches for molecular characterization and structure-based functional elucidation of a hypothetical protein from Mycobacterium tuberculosis.Genomics & informatics · 2023Article
- B and T Cell Epitopes of the Incursionary Foot-and-Mouth Disease Virus Serotype SAT2 for Vaccine Development.Viruses · 2023Review
- COVID-19 Vaccines: Computational tools and Development.Informatics in medicine unlocked · 2023Review
- Functional reconstitution of the MERS CoV receptor binding motif.Molecular immunology · 2022Article
- Intranasal administration of immunogenic poly-epitope fromIranian journal of basic medical sciences · 2021Article
- From Structural Studies to HCV Vaccine Design.Viruses · 2021Review
- DNA vaccines against COVID-19: Perspectives and challenges.Life sciences · 2021Review
- Resources and computational strategies to advance small molecule SARS-CoV-2 discovery: Lessons from the pandemic and preparing for future health crises.Computational and structural biotechnology journal · 2021Review
- Quantitative evaluation of protective antibody response induced by hepatitis E vaccine in humans.Nature communications · 2020Article
- COVID-19 and SARS-CoV-2. Modeling the present, looking at the future.Physics reports · 2020Review
- Article
- Potential Inhibitors for Novel Coronavirus Protease Identified by Virtual Screening of 606 Million Compounds.International journal of molecular sciences · 2020Article
- Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines.Science advances · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Rational approaches will be required to develop universal vaccines for viral pathogens such as human immunodeficiency virus, hepatitis C virus, and influenza, for which empirical approaches have failed. The main objective of a rational vaccine strategy is to design novel immunogens that are capable of inducing long-term protective immunity. In practice, this requires structure-based engineering of the target neutralizing epitopes and a quantitative readout of vaccine-induced immune responses. Therefore, computational tools that can facilitate these two areas have played increasingly important roles in rational vaccine design in recent years. Here we review the computational techniques developed for protein structure prediction and antibody repertoire analysis, and demonstrate how they can be applied to the design and evaluation of epitope vaccines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.