ArticleMedical oncology (Northwood, London, England)2015
Chemoradiation therapy reduces aldehyde dehydrogenase 1 expression in cervical cancer but does not improve patient survival.
Article in Medical oncology (Northwood, London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.
- The Prognostic Value of Cancer Stem Cell Markers in Cervical Cancer: A Systematic Review and Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2021Pooled it
- Low P16International journal of molecular sciences · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aldehyde dehydrogenase 1 (ALDH-1) is a cancer stem cell marker whose overexpression can predict the prognosis of several human cancers. In this study, we assessed ALDH-1 expression in cervical cancer tissues and investigated the usefulness of ALDH-1 expression levels for the prediction of patient response to chemoradiation therapy and survival. Tissue samples from 74 patients were examined via immunostaining with ALDH-1 antibody before and after chemoradiation therapy. Twenty-nine of the 74 cervical cancer cases exhibited ALDH-1 expression (39.19 %) in the pre-treatment tissue samples; however, only 19 of these 39 cases exhibited ALDH-1 expression (48.72 %) in post-treatment tissue samples, indicating that chemoradiotherapy eliminated the ALDH-1 positive tumor stem cells in cervical cancer. However, patient disease-free survival was not associated with ALDH-1 expression (11.78 ± 1.95 vs. 12.50 ± 1.91 months in ALDH-1-positive and -negative tumors, respectively). This study indicates that the reduction of the cancer stem cell population via chemoradiotherapy may not be sufficient to improve patient survival. Thus, the clinical value of ALDH-1 expression in cervical cancer may need to be re-examined.
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