Evidence map›Paper›PMID 25837340›Full record

ArticleJournal of the mechanical behavior of biomedical materials2015

Correlations between transmural mechanical and morphological properties in porcine thoracic descending aorta.

Ali Hemmasizadeh, Alkiviadis Tsamis, Rabee Cheheltani, Soroush Assari, Antonio D'Amore, Michael Autieri, Mohammad F Kiani, Nancy Pleshko, William R Wagner, Simon C Watkins and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the mechanical behavior of biomedical materials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  4. Review
  5. Article
  6. [Experimental study on mechanical properties of the ventral and the dorsal tissues of porcine descending aorta].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Ali HemmasizadehDepartments of Mechanical Engineering, Temple University, Philadelphia, USA.
Alkiviadis TsamisDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Rabee CheheltaniDepartments of Mechanical Engineering, Temple University, Philadelphia, USA.
Soroush AssariDepartments of Mechanical Engineering, Temple University, Philadelphia, USA.
Antonio D'AmoreMcGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Michael AutieriDepartments of Physiology, Temple University, Philadelphia, USA.
Mohammad F KianiDepartments of Mechanical Engineering, Temple University, Philadelphia, USA; Departments of Bioengineering, Temple University, Philadelphia, USA.
Nancy PleshkoDepartments of Bioengineering, Temple University, Philadelphia, USA.
William R WagnerDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Simon C WatkinsCenter for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA, USA.
David VorpDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Kurosh DarvishDepartments of Mechanical Engineering, Temple University, Philadelphia, USA; Departments of Bioengineering, Temple University, Philadelphia, USA. Electronic address: kdarvish@temple.edu.
Temple University · USUniversity of Pittsburgh · USMcGowan Institute for Regenerative Medicine · US

Funding

miRNA-mediated reduction of VSMC foam cell formationR01HL117724 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI AUTIERI, MICHAEL V · 2013 to 2022
$3.8M
Attenuation of atherosclerosis by regulation of VSMC inflammatory gene mRNA stabilityR01HL141108 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI AUTIERI, MICHAEL V · 2018 to 2021
$2.0M
Mechanisms of Traumatic Rupture in ArteriesK25HL086512 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI DARVISH, KUROSH K · 2008 to 2012
$729k
Development of Experimental and Computational Models for Traumatic Aortic RuptureR21HL088159 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI DARVISH, KUROSH K · 2008 to 2009
$400k
NHLBI NIH HHS K25 HL086512NHLBI NIH HHS K25HL086512-05NHLBI NIH HHS R01 HL117724NHLBI NIH HHS R01 HL141108NHLBI NIH HHS R21 HL088159NHLBI NIH HHS R21 HL088159-02
6 · The paper itself

Abstract

Determination of correlations between transmural mechanical and morphological properties of aorta would provide a quantitative baseline for assessment of preventive and therapeutic strategies for aortic injuries and diseases. A multimodal and multidisciplinary approach was adopted to characterize the transmural morphological properties of descending porcine aorta. Histology and multi-photon microscopy were used for describing the media layer micro-architecture in the circumferential-radial plane, and Fourier Transform infrared imaging spectroscopy was utilized for determining structural protein, and total protein content. The distributions of these quantified properties across the media thickness were characterized and their relationship with the mechanical properties from a previous study was determined. Our findings indicate that there is an increasing trend in the instantaneous Young׳s modulus (E), elastic lamella density (ELD), structural protein (SPR), total protein (TPR), and elastin and collagen circumferential percentage (ECP and CCP) from the inner towards the outer layers. Two regions with equal thickness (inner and outer halves) were determined with significantly different morphological and material properties. The results of this study represent a substantial step toward anatomical characterization of the aortic wall building blocks and establishment of a foundation for quantifying the role of microstructural components on the functionality of aorta.

Indexed as

Mechanical PhenomenaSwineAnimalsAorta, ThoracicBiomechanical PhenomenaElastic ModulusExtracellular MatrixMaterials TestingNanotechnologyAortaCollagenElastinFiber orientationFourier Transform infrared imaging spectroscopyMorphologyMulti-photon microscopyNanoindentation

Identifiers

PMID25837340
PMCPMC4430388
OpenAlexW2038692351

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.