Trial reportThe European respiratory journal2015
A randomised trial of lung sealant versus medical therapy for advanced emphysema.
Trial report in The European respiratory journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 6 syntheses or guidelines pooled it, 121 citations in OpenAlex.
- Extrapulmonary effects of lung volume reduction in severe emphysema: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Pooled it
- Impact of bronchoscopic thermal vapor ablation on lung volume reduction in patients with emphysema: a meta-analysis.BMC pulmonary medicine · 2023Pooled it
- Bronchoscopic lung volume reduction procedures for emphysema: A network meta-analysis.Medicine · 2020Pooled it
- Bronchoscopic lung volume reduction procedures for chronic obstructive pulmonary disease.The Cochrane database of systematic reviews · 2017Pooled it
- Lung volume reduction surgery for diffuse emphysema.The Cochrane database of systematic reviews · 2016Pooled it
- Reversal of collateral ventilation using endoscopic polymer foam in COPD patients undergoing endoscopic lung volume reduction with endobronchial valves: A controlled parallel group trial.Respirology (Carlton, Vic.) · 2022Trial
- Connecting the dots: historical perspective on lung volume reduction.Journal of thoracic disease · 2026Review
- The Rise and Fall of Interventional Pulmonology Procedures: Lessons in Innovation, Evidence, and Abandonment.Diagnostics (Basel, Switzerland) · 2026Review
- Surgical and bronchoscopic pulmonary function-improving procedures in lung emphysema.European respiratory review : an official journal of the European Respiratory Society · 2023Review
- Bronchoscopic Management of COPD and Advances in Therapy.Life (Basel, Switzerland) · 2023Review
- Which Endoscopic Procedure to Use and in What Patient? Valves, Coils, Foam, and Heat in COPD and Asthma.Pulmonary therapy · 2023Review
- Current status of interventional therapy for pulmonary emphysema with bronchoscopy.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022Review
- Crosslink bio-adhesives for bronchoscopic lung volume reduction: current status and future direction.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- New bronchoscopic treatment modalities for patients with chronic bronchitis.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Bronchoscopic management of asthma, COPD and emphysema.European respiratory review : an official journal of the European Respiratory Society · 2021Article
- Bronchoscopic lung volume reduction: status quo.Annals of translational medicine · 2020Review
- Patient Selection for Bronchoscopic Lung Volume Reduction.International journal of chronic obstructive pulmonary disease · 2020Article
- [Imaging before and after endoscopic lung volume reduction].Der Radiologe · 2019Article
- Efficacy and Safety of Stent, Valves, Vapour ablation, Coils and Sealant Therapies in Advanced Emphysema: A Meta-Analysis.Turkish thoracic journal · 2019Review
Corrections and comments
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Authors and funding
37 authors at 1 institution in 1 country.
Funding
Abstract
Uncontrolled pilot studies demonstrated promising results of endoscopic lung volume reduction using emphysematous lung sealant (ELS) in patients with advanced, upper lobe predominant emphysema. We aimed to evaluate the safety and efficacy of ELS in a randomised controlled setting.Patients were randomised to ELS plus medical treatment or medical treatment alone. Despite early termination for business reasons and inability to assess the primary 12-month end-point, 95 out of 300 patients were successfully randomised, providing sufficient data for 3- and 6-month analysis.57 patients (34 treatment and 23 control) had efficacy results at 3 months; 34 (21 treatment and 13 control) at 6 months. In the treatment group, 3-month lung function, dyspnoea, and quality of life improved significantly from baseline when compared to control. Improvements persisted at 6 months with >50% of treated patients experiencing clinically important improvements, including some whose lung function improved by >100%. 44% of treated patients experienced adverse events requiring hospitalisation (2.5-fold more than control, p=0.01), with two deaths in the treated cohort. Treatment responders tended to be those experiencing respiratory adverse events.Despite early termination, results show that minimally invasive ELS may be efficacious, yet significant risks (probably inflammatory) limit its current utility.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.