Evidence map›Paper›PMID 25837040›Full record

Observational studyThe European respiratory journal2015

Management of patients with idiopathic pulmonary fibrosis in clinical practice: the INSIGHTS-IPF registry.

Jürgen Behr, Michael Kreuter, Marius M Hoeper, Hubert Wirtz, Jens Klotsche, Dirk Koschel, Stefan Andreas, Martin Claussen, Christian Grohé, Henrike Wilkens and 16 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The European respiratory journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01695408 (Investigating Significant Health Trends in IPF), which is not on this map. Cited by 111 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01695408 completednot on this map

Investigating Significant Health Trends in IPF (INSIGHTS-IPF). Nationwide Prospective Registry.

TypeobservationalSponsorTechnische Universität DresdenRan2012 to 2021Enrolled1,232ConditionsIdiopathic Pulmonary Fibrosis
3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Pooled it
  7. Trial
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  13. Article
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  16. Observational
  17. Cough and dyspnea management in pulmonary fibrosis.Current opinion in supportive and palliative care · 2025
    Review
  18. Review
  19. Article
  20. Article

51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors.

Jürgen BehrStudy steering committee members j.behr@asklepios.com.
Michael KreuterStudy steering committee members.
Marius M HoeperStudy steering committee members.
Hubert WirtzStudy steering committee members.
Jens KlotscheStudy steering committee members.
Dirk KoschelFor the authors' affiliations, see the Acknowledgements Study steering committee members.
Stefan AndreasFor the authors' affiliations, see the Acknowledgements Study steering committee members.
Martin ClaussenFor the authors' affiliations, see the Acknowledgements Study steering committee members.
Christian GrohéFor the authors' affiliations, see the Acknowledgements Study steering committee members.
Henrike WilkensFor the authors' affiliations, see the Acknowledgements Study steering committee members.
Winfried RanderathFor the authors' affiliations, see the Acknowledgements Study steering committee members.
Dirk SkowaschFor the authors' affiliations, see the Acknowledgements Study steering committee members.
F Joachim MeyerFor the authors' affiliations, see the Acknowledgements Study steering committee members.
Joachim KirschnerFor the authors' affiliations, see the Acknowledgements Study steering committee members.
Sven GläserFor the authors' affiliations, see the Acknowledgements Study steering committee members.
Felix J F HerthFor the authors' affiliations, see the Acknowledgements Study steering committee members.
Tobias WelteFor the authors' affiliations, see the Acknowledgements Study steering committee members.
Rudolf Maria HuberFor the authors' affiliations, see the Acknowledgements Study steering committee members.
Claus NeurohrFor the authors' affiliations, see the Acknowledgements Study steering committee members.
Martin SchwaiblmairFor the authors' affiliations, see the Acknowledgements Study steering committee members.
Martin KohlhäuflFor the authors' affiliations, see the Acknowledgements Study steering committee members.
Gert HöffkenFor the authors' affiliations, see the Acknowledgements Study steering committee members.
Matthias HeldFor the authors' affiliations, see the Acknowledgements Study steering committee members.
Andrea KochFor the authors' affiliations, see the Acknowledgements Study steering committee members.
Thomas BahmerFor the authors' affiliations, see the Acknowledgements Study steering committee members.
David PittrowStudy steering committee members.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

After introduction of the new international guidelines on idiopathic pulmonary fibrosis (IPF) in 2011, we investigated clinical management practices for patients with IPF according to physicians' diagnoses. A prospective, multicenter, noninterventional study with comprehensive quality measures including on-site source data verification was performed in Germany. 502 consecutive patients (171 newly diagnosed, 331 prevalent; mean±SD age 68.7±9.4 years, 77.9% males) with a mean disease duration of 2.3±3.5 years were enrolled. IPF diagnosis was based on clinical assessments and high-resolution computed tomography (HRCT) in 90.2%, and on surgical lung biopsy combined with histology in 34.1% (lavage in 61.8%). The median 6-min walk distance was 320 m (mean 268±200 m). The mean forced vital capacity was 72±20% pred and diffusing capacity of the lung for carbon monoxide was 35±15% pred. No drugs were administered in 17.9%, oral steroids in 23.7%, N-acetylcysteine in 33.7%, pirfenidone in 44.2% and other drugs in 4.6% of patients. Only 2.8% of the cohort was listed for lung transplantation. IPF patients were diagnosed in line with the new guidelines. They had more severe disease than those enrolled in recent randomised controlled trials. In addition to HRCT, the frequency of lung biopsies was surprisingly high. Treatment patterns varied substantially.

Indexed as

AcetylcysteineAgedAnti-Inflammatory Agents, Non-SteroidalBiopsyExercise TestFemaleGermanyHumansIdiopathic Pulmonary FibrosisLungMaleMiddle AgedPractice Guidelines as TopicProspective StudiesPyridonesRegistriesAcetylcysteineAnti-Inflammatory Agents, Non-SteroidalpirfenidonePyridonesSteroids

Identifiers

PMID25837040
PMCPMC4486374

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.