Evidence map›Paper›PMID 25836258›Full record

ArticlePloS one2015

Association between ankylosing spondylitis and the miR-146a and miR-499 polymorphisms.

Hui Ying Xu, Zhang Yang Wang, Jing Feng Chen, Tian Yang Wang, Ling Ling Wang, Li Li Tang, Xian-yang Lin, Chun-wu Zhang, Bi-cheng Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Genetic variant inAnnals of medicine · 2021
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  12. Consequences of genetic variants in miRNA genes.Computational and structural biotechnology journal · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hui Ying XuKey Laboratory of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Zhang Yang WangKey Laboratory of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Jing Feng ChenDepartment of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Tian Yang WangDepartment of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Ling Ling WangKey Laboratory of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Li Li TangKey Laboratory of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Xian-yang LinInjury Orthopaedics of Traditional Chinese medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Chun-wu ZhangInjury Orthopaedics of Traditional Chinese medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Bi-cheng ChenKey Laboratory of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

miRNAs are small, non-coding RNAs that regulate the expression of multiple target genes at the post-transcriptional level. Single-nucleotide polymorphisms (SNPs) in miRNA sequences may alter miRNA expression and have been implicated in the pathogenesis of multiple forms of arthritis, including rheumatoid arthritis (RA) and osteoarthritis. The present study explored the association between ankylosing spondylitis (AS) and two single nucleotide polymorphisms (SNPs), miR-146a rs2910164G>C and miR-499 rs3746444T>C, in a Han Chinese population. A case-control study consisting of 102 subjects with AS and 105 healthy controls was designed. The two miRNA SNPs were identified by direct sequencing. Subsequently, their gene and genotype frequencies were compared with healthy controls. A significant difference was observed in the miR-146a rs2910164G>C SNP. The frequency of the G allele was markedly higher in the AS patients than in the healthy controls (P = 0.005, Pc = 0.01, OR = 1.787), and the frequency of the GG genotype was higher in AS patients than in controls (P = 0.014, Pc = 0.042, OR = 2.516). However, no significant association was found between the miR-499 rs3746444T>C variant and susceptibility to AS. This is the first study to address the association between the miR-146a rs2910164G>C and miR-499 rs3746444T>C polymorphisms and AS, and it suggests a potential pathogenic factor for AS. Further studies are needed to validate our findings in a larger series, as well as in other ethnic backgrounds.

Indexed as

Polymorphism, Single NucleotideAdolescentAdultAgedAsian PeopleCase-Control StudiesChinaFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseHumansMaleMicroRNAsMiddle AgedSpondylitis, AnkylosingMicroRNAsMIRN146 microRNA, humanMIRN499 microRNA, human

Identifiers

PMID25836258
PMCPMC4383612

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.