ArticlePLoS genetics2015
The evolutionary origination and diversification of a dimorphic gene regulatory network through parallel innovations in cis and trans.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 52 citations in OpenAlex.
- The influence of Polycomb and Trithorax group function on the sexually dimorphic abdomen pigmentation of Drosophila melanogaster.G3 (Bethesda, Md.) · 2026Article
- Evolution of dominance in a Mendelian trait is linked to the evolution of environmental plasticity.Evolution; international journal of organic evolution · 2026Article
- The transcriptomics of phenotypic nonspecificity in Drosophila melanogaster.G3 (Bethesda, Md.) · 2025Article
- Redundant and Singular Regulatory Elements Underlie the Rapidly Evolving Pigmentation of Drosophila.Molecular biology and evolution · 2025Article
- Evolution of dominance in a Mendelian trait is linked to the evolution of environmental plasticity.bioRxiv : the preprint server for biology · 2025Article
- A genetic screen of transcription factors in the Drosophila melanogaster abdomen identifies novel pigmentation genes.G3 (Bethesda, Md.) · 2024Article
- Changes in locus wide repression underlie the evolution of Drosophila abdominal pigmentation.PLoS genetics · 2023Article
- A novel role for trithorax in the gene regulatory network for a rapidly evolving fruit fly pigmentation trait.PLoS genetics · 2023Article
- Article
- Review
- The regulation of a pigmentation gene in the formation of complex color patterns in Drosophila abdomens.PloS one · 2022Article
- Redundant enhancers in the iab-5 domain cooperatively activate Abd-B in the A5 and A6 abdominal segments of Drosophila.Development (Cambridge, England) · 2021Article
- Mapping of functional elements of the Fab-6 boundary involved in the regulation of the Abd-B hox gene in Drosophila melanogaster.Scientific reports · 2021Article
- The modular expression patterns of three pigmentation genes prefigure unique abdominal morphologies seen among three Drosophila species.Gene expression patterns : GEP · 2020Article
- Red Light/Green Light, a Dual Fluorescent Protein Reporter System To Study Enhancer-Promoter Specificity inG3 (Bethesda, Md.) · 2020Article
- Modular cis-regulatory logic of yellow gene expression in silkmoth larvae.Insect molecular biology · 2019Article
- Changes throughout a Genetic Network Mask the Contribution of Hox Gene Evolution.Current biology : CB · 2019Article
- Redundant and Cryptic Enhancer Activities of theGenetics · 2019Article
- Boundaries mediate long-distance interactions between enhancers and promoters in the Drosophila Bithorax complex.PLoS genetics · 2018Article
- Augmentation of a wound response element accompanies the origin of a Hox-regulated Drosophila abdominal pigmentation trait.Developmental biology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The origination and diversification of morphological characteristics represents a key problem in understanding the evolution of development. Morphological traits result from gene regulatory networks (GRNs) that form a web of transcription factors, which regulate multiple cis-regulatory element (CRE) sequences to control the coordinated expression of differentiation genes. The formation and modification of GRNs must ultimately be understood at the level of individual regulatory linkages (i.e., transcription factor binding sites within CREs) that constitute the network. Here, we investigate how elements within a network originated and diversified to generate a broad range of abdominal pigmentation phenotypes among Sophophora fruit flies. Our data indicates that the coordinated expression of two melanin synthesis enzymes, Yellow and Tan, recently evolved through novel CRE activities that respond to the spatial patterning inputs of Hox proteins and the sex-specific input of Bric-à-brac transcription factors. Once established, it seems that these newly evolved activities were repeatedly modified by evolutionary changes in the network's trans-regulators to generate large-scale changes in pigment pattern. By elucidating how yellow and tan are connected to the web of abdominal trans-regulators, we discovered that the yellow and tan abdominal CREs are composed of distinct regulatory inputs that exhibit contrasting responses to the same Hox proteins and Hox cofactors. These results provide an example in which CRE origination underlies a recently evolved novel trait, and highlights how coordinated expression patterns can evolve in parallel through the generation of unique regulatory linkages.
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