Evidence map›Paper›PMID 25835948›Full record

ArticlePloS one2015

Diagnostic confidence of run-off CT-angiography as the primary diagnostic imaging modality in patients presenting with acute or chronic peripheral arterial disease.

Thomas Werncke, Kristina Imeen Ringe, Christian von Falck, Martin Kruschewski, Frank Wacker, Bernhard Christian Meyer

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06782100 (MRI Guided Management of Occlusive Peripheral Arterial Disease), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06782100 recruitingnot on this mapstarted 2024, after this paper: background citation

MRI Guided Management of Occlusive Peripheral Arterial Disease

Typeobservational_patient_registrySponsorThe Methodist Hospital Research InstituteRan2024 to 2029Enrolled175ConditionsPeripheral Vascular Diseases
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Thomas WernckeKlinik für Radiologie, Charité Universitätsmedizin Berlin, Berlin, Germany.
Kristina Imeen RingeInstitute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.
Christian von FalckInstitute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.
Martin KruschewskiKlinik für Radiologie, Charité Universitätsmedizin Berlin, Berlin, Germany.
Frank WackerInstitute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.
Bernhard Christian MeyerKlinik für Radiologie, Charité Universitätsmedizin Berlin, Berlin, Germany.
Charité - Universitätsmedizin Berlin · DEMedizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the reliability of CT-angiography of the lower extremities (run-off CTA) to derive a treatment decision in patients with acute and chronic peripheral artery disease (PAD). MATERIALS AND

methods314 patients referred for run-off CTA were includ-ed in this retrospective study. First, diagnostic confidence of run-off CTA to derive a treat-ment decision was assessed in an interdisciplinary vascular conference using a 2 point scale (sufficient or not sufficient diagnostic confidence) and compared with the image quality eval-uated by two readers in consensus in four different levels (abdominopelvic, thigh, calf, foot arteries). Second, reliability of treatment decision was verified in all patients undergoing re-vascularization therapy.

resultsDiagnostic confidence of run-off CTA to derive a treatment deci-sion was sufficient in all patients with acute and in 97% of patients (215/221) with chronic PAD, whereas the rate of run-off CTA with non-diagnostic image quality was considerably higher in the calf and foot level (acute vs. chronic; calf: 28% vs.17%; foot: 52% vs. 20%). Reliability of treatment decision was superior for patients with chronic (123/133 = 92%) than for patients with acute PAD (64/78 = 82%, P = 0.02).

conclusionRun-off CTA is a reliable imaging modality for primary diag-nostic work-up of patients with acute and chronic PAD.

Indexed as

Acute DiseaseAngiographyChronic DiseaseClinical Decision-MakingFemaleHumansImage Processing, Computer-AssistedMalePeripheral Arterial DiseaseReproducibility of ResultsRetrospective StudiesRisk FactorsTomography, X-Ray Computed

Identifiers

PMID25835948
PMCPMC4383442
OpenAlexW2038250923

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.