ArticlePLoS genetics2015
Nxf1 natural variant E610G is a semi-dominant suppressor of IAP-induced RNA processing defects.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- NXF1 suppresses progression of endometrial cancer by interacting with the SRSF3 to regulate SP4 splicing.iScience · 2025Article
- Resolution of structural variation in diverse mouse genomes reveals chromatin remodeling due to transposable elements.Cell genomics · 2023Article
- CRISPR/Cas9 mediated somatic gene therapy for insertional mutations: thePrecision clinical medicine · 2021Article
- The lipid elongation enzyme ELOVL2 is a molecular regulator of aging in the retina.Aging cell · 2020Article
- Chromatin-associated RNAs as facilitators of functional genomic interactions.Nature reviews. Genetics · 2019Review
- Deleting an Nr4a1 Super-Enhancer Subdomain Ablates Ly6CImmunity · 2016Article
- Allele, phenotype and disease data at Mouse Genome Informatics: improving access and analysis.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- Nmf9 Encodes a Highly Conserved Protein Important to Neurological Function in Mice and Flies.PLoS genetics · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Endogenous retroviruses and retrotransposons contribute functional genetic variation in animal genomes. In mice, Intracisternal A Particles (IAPs) are a frequent source of both new mutations and polymorphism across laboratory strains. Intronic IAPs can induce alternative RNA processing choices, including alternative splicing. We previously showed IAP I∆1 subfamily insertional mutations are suppressed by a wild-derived allele of the major mRNA export factor, Nxf1. Here we show that a wider diversity of IAP insertions present in the mouse reference sequence induce insertion-dependent alternative processing that is suppressed by Nxf1CAST alleles. These insertions typically show more modest gene expression changes than de novo mutations, suggesting selection or attenuation. Genome-wide splicing-sensitive microarrays and gene-focused assays confirm specificity of Nxf1 genetic modifier activity for IAP insertion alleles. Strikingly, CRISPR/Cas9-mediated genome editing demonstrates that a single amino acid substitution in Nxf1, E610G, is sufficient to recreate a quantitative genetic modifier in a co-isogenic background.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.