Evidence map›Paper›PMID 25835729›Full record

ReviewVirology2015

Shake, rattle, and roll: Impact of the dynamics of flavivirus particles on their interactions with the host.

Richard J Kuhn, Kimberly A Dowd, Carol Beth Post, Theodore C Pierson

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 107 citations in OpenAlex.

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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Richard J KuhnDepartments of Biological Sciences and Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA. Electronic address: kuhnr@purdue.edu.
Kimberly A DowdViral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: dowdka@mail.nih.gov.
Carol Beth PostDepartments of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA. Electronic address: cbp@purdue.edu.
Theodore C PiersonViral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: piersontc@mail.nih.gov.
National Institutes of Health · USPurdue University West Lafayette · US

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI John Tesmer · 1985 to 2026
$43.4M
Mechanisms of Antibody-Mediated Neutralization of Flavivirus InfectionZIAAI000957 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI PIERSON, THEODORE · 2009 to 2019
$7.1M
PROTEIN STRUCTURE STABILIZATION AND ACTIVITY IN HUMAN RHR01AI039639 · NIAID · PURDUE UNIVERSITY WEST LAFAYETTE · PI POST, CAROL B. · 1997 to 2011
$2.2M
Intramural NIH HHSNCI NIH HHS P30 CA023168NIAID NIH HHS AI000957NIAID NIH HHS R01 AI039639
6 · The paper itself

Abstract

Remarkable progress in structural biology has equipped virologists with insight into structures of viral proteins and virions at increasingly high resolution. Structural information has been used extensively to address fundamental questions about virtually all aspects of how viruses replicate in cells, interact with the host, and in the design of antiviral compounds. However, many critical aspects of virology exist outside the snapshots captured by traditional methods used to generate high-resolution structures. Like all proteins, viral proteins are not static structures. The conformational flexibility and dynamics of proteins play a significant role in protein-protein interactions, and in the structure and biology of virus particles. This review will discuss the implications of the dynamics of viral proteins on the biology, antigenicity, and immunogenicity of flaviviruses.

Indexed as

Host-Pathogen InteractionsAntigens, ViralFlavivirusProtein ConformationViral ProteinsAntigens, ViralViral ProteinsAntibody-mediated neutralizationDengue virusFlavivirusStructural dynamicsViral breathingWest Nile virus

Identifiers

PMID25835729
PMCPMC4900690
OpenAlexW2019193901

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.