Evidence map›Paper›PMID 25835574›Full record

ArticleVaccine2015

Influenza vaccination in children with neurologic or neurodevelopmental disorders.

Michael Smith, Georgina Peacock, Timothy M Uyeki, Cynthia Moore

Open access · greenAbstract read
In one paragraph

Article in Vaccine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Disparities in Seasonal Influenza Vaccination in Europe.Immunity, inflammation and disease · 2025
    Review
  4. Article
  5. Guideline-Concordant Antiviral Treatment in Children at High Risk for Influenza Complications.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  6. Article
  7. Article
  8. Multi-Organ Dysfunction in Cerebral Palsy.Frontiers in pediatrics · 2021
    Review
  9. Article
  10. Vaccination in people with disability: a review.Human vaccines & immunotherapeutics · 2020
    Review
  11. Article
  12. Article
  13. Article
  14. Canadian family physician Medecin de famille canadien · 2018
    Article
  15. Article
  16. Fever in Children: Pearls and Pitfalls.Children (Basel, Switzerland) · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Michael SmithDepartment of Pediatrics, University of Louisville School of Medicine, United States. Electronic address: mjsmit22@louisville.edu.
Georgina PeacockNational Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, United States.
Timothy M UyekiInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, United States.
Cynthia MooreNational Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, United States.
Centers for Disease Control and Prevention · USNational Center on Birth Defects and Developmental Disabilities · USUniversity of Louisville · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

backgroundChildren with neurologic or neurodevelopmental disorders (NNDDs) are at increased risk of complications from influenza. Although the Advisory Committee on Immunization Practices (ACIP) has recognized NNDDs as high-risk conditions for influenza complications since 2005, little is known about influenza vaccination practices in this population.

methodsCDC collaborated with Family Voices, a national advocacy group for children with special healthcare needs, to recruit parents of children with chronic medical conditions. Parents were surveyed about their knowledge, attitudes, and practices surrounding influenza vaccination. The primary outcome of interest was parental report of vaccination, or intent to vaccinate, at the time of survey participation. CDC also collaborated with the American Academy of Pediatrics to recruit primary care and specialty physicians who provide care for high-risk children, specifically those with neurologic conditions. The primary outcome was physician recognition of ACIP high-risk influenza conditions.

results2138 surveys were completed by parents of children with high-risk conditions, including 1143 with at least one NNDD. Overall, 50% of children with an NNDD were vaccinated, or their parents planned to have them vaccinated against influenza. Among all 2138 children, in multivariable analysis, the presence of a respiratory condition and prior seasonal influenza vaccination was significantly associated with receipt or planned current season influenza vaccination, but the presence of an NNDD was not. 412 pediatricians completed the provider survey. Cerebral palsy was recognized as a high-risk influenza condition by 74% of physician respondents, but epilepsy (51%) and intellectual disability (46%) were less commonly identified.

conclusionsOur estimates of influenza vaccination in children with NNDDs are comparable to published reports of vaccination in healthy children, which continue to be suboptimal. Education of parents of children with NNDDs and healthcare providers about influenza and the benefit of annual influenza vaccination is needed.

Indexed as

Neurodevelopmental DisordersAdultCenters for Disease Control and Prevention, U.S.Cerebral PalsyChildChild, PreschoolEpilepsyFemaleHealth Knowledge, Attitudes, PracticeHealth PersonnelHumansInfluenza, HumanIntellectual DisabilityMaleParentsRisk FactorsDisabilityHigh-riskImmunizationInfluenzaNeurologic

Identifiers

PMID25835574
PMCPMC4483265
OpenAlexW2052994262

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.