Evidence map›Paper›PMID 25835490›Full record

SynthesisJournal of clinical epidemiology2015

Inadequate use and regulation of interventions against publication bias decreases their effectiveness: a systematic review.

Kylie Thaler, Christina Kien, Barbara Nussbaumer, Megan G Van Noord, Ursula Griebler, Irma Klerings, Gerald Gartlehner, UNCOVER Project Consortium

Abstract readEvaluation StudySystematic Review
In one paragraph

Synthesis in Journal of clinical epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Bias in Medicine: Lessons Learned and Mitigation Strategies.JACC. Basic to translational science · 2021
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kylie ThalerDepartment for Evidence-based Medicine and Clinical Epidemiology, Danube University Krems, Dr.-Karl-Dorrek Str. 30 Krems an der Donau 3500, Austria. Electronic address: kylie.thaler@donau-uni.ac.at.
Christina KienDepartment for Evidence-based Medicine and Clinical Epidemiology, Danube University Krems, Dr.-Karl-Dorrek Str. 30 Krems an der Donau 3500, Austria.
Barbara NussbaumerDepartment for Evidence-based Medicine and Clinical Epidemiology, Danube University Krems, Dr.-Karl-Dorrek Str. 30 Krems an der Donau 3500, Austria.
Megan G Van NoordDepartment for Evidence-based Medicine and Clinical Epidemiology, Danube University Krems, Dr.-Karl-Dorrek Str. 30 Krems an der Donau 3500, Austria.
Ursula GrieblerDepartment for Evidence-based Medicine and Clinical Epidemiology, Danube University Krems, Dr.-Karl-Dorrek Str. 30 Krems an der Donau 3500, Austria.
Irma KleringsDepartment for Evidence-based Medicine and Clinical Epidemiology, Danube University Krems, Dr.-Karl-Dorrek Str. 30 Krems an der Donau 3500, Austria.
Gerald GartlehnerDepartment for Evidence-based Medicine and Clinical Epidemiology, Danube University Krems, Dr.-Karl-Dorrek Str. 30 Krems an der Donau 3500, Austria; Research Triangle Institute International, Research Triangle Park, 3040 East Cornwallis Road Research Triangle Park, NC 27709-2194, USA.
UNCOVER Project Consortium

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo determine the effectiveness of interventions designed to prevent or reduce publication and related biases. STUDY DESIGN AND

settingWe searched multiple databases and performed manual searches using terms related to publication bias and known interventions against publication bias. We dually reviewed citations and assessed risk of bias. We synthesized results by intervention and outcomes measured and graded the quality of the evidence (QoE).

resultsWe located 38 eligible studies. The use of prospective trial registries (PTR) has increased since 2005 (seven studies, moderate QoE); however, positive outcome-reporting bias is prevalent (14 studies, low QoE), and information in nonmandatory fields is vague (10 studies, low QoE). Disclosure of financial conflict of interest (CoI) is inadequate (five studies, low QoE). Blinding peer reviewers may reduce geographical bias (two studies, very low QoE), and open-access publishing does not discriminate against authors from low-income countries (two studies, very low QoE).

conclusionThe use of PTR and CoI disclosures is increasing; however, the adequacy of their use requires improvement. The effect of open-access publication and blinding of peer reviewers on publication bias is unclear, as is the effect of other interventions such as electronic publication and authors' rights to publish their results.

Indexed as

Access to InformationConflict of InterestCost-Benefit AnalysisDisclosurePeer ReviewPractice Guidelines as TopicProgram EvaluationProspective StudiesPublication BiasRandomized Controlled Trials as TopicRegistriesConflict of interestGeographical biasOpen accessPeer reviewPublication biasTrial registration

Identifiers

PMID25835490
PMCPMC4459964

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.