Evidence map›Paper›PMID 25835462›Full record

Trial reportAIDS and behavior2015

Behavioral intervention improves treatment outcomes among HIV-infected individuals who have delayed, declined, or discontinued antiretroviral therapy: a randomized controlled trial of a novel intervention.

Marya Gwadz, Charles M Cleland, Elizabeth Applegate, Mindy Belkin, Monica Gandhi, Nadim Salomon, Angela Banfield, Noelle Leonard, Marion Riedel, Hannah Wolfe and 6 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in AIDS and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.

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  18. Antiretroviral Concentrations in Hair Strongly Predict Virologic Response in a Large Human Immunodeficiency Virus Treatment-naive Clinical Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Marya GwadzCenter for Drug Use and HIV Research (CDUHR), New York University College of Nursing, 433 First Avenue, 7th Floor, New York, NY, 10010, USA. mg2890@nyu.edu.
Charles M ClelandCenter for Drug Use and HIV Research (CDUHR), New York University College of Nursing, 433 First Avenue, 7th Floor, New York, NY, 10010, USA. cmc13@nyu.edu.
Elizabeth ApplegateCenter for Drug Use and HIV Research (CDUHR), New York University College of Nursing, 433 First Avenue, 7th Floor, New York, NY, 10010, USA. eaa6@nyu.edu.
Mindy BelkinCenter for Drug Use and HIV Research (CDUHR), New York University College of Nursing, 433 First Avenue, 7th Floor, New York, NY, 10010, USA. mjf223@nyu.edu.
Monica GandhiDivision of HIV/AIDS, Department of Medicine, University of California San Francisco (UCSF), San Francisco, CA, USA. monica.gandhi@ucsf.edu.
Nadim SalomonDepartment of Infectious Diseases, Peter Krueger Center for Immunological Disorders, Mount Sinai Beth Israel, New York, NY, USA. nsalomon@chpnet.org.
Angela BanfieldCenter for Drug Use and HIV Research (CDUHR), New York University College of Nursing, 433 First Avenue, 7th Floor, New York, NY, 10010, USA. adb12@nyu.edu.
Noelle LeonardCenter for Drug Use and HIV Research (CDUHR), New York University College of Nursing, 433 First Avenue, 7th Floor, New York, NY, 10010, USA. nrl4@nyu.edu.
Marion RiedelSchool of Social Work, Columbia University, New York, NY, USA. mr108@columbia.edu.
Hannah WolfeMount Sinai St. Luke's-Roosevelt Hospital Center, Spencer Cox Center for Health, New York, NY, USA. hannahlahozwolfe@gmail.com.
Isaiah PickensCenter for Drug Use and HIV Research (CDUHR), New York University College of Nursing, 433 First Avenue, 7th Floor, New York, NY, 10010, USA. isaiah.pickens@gmail.com.
Kelly BolgerCenter for Drug Use and HIV Research (CDUHR), New York University College of Nursing, 433 First Avenue, 7th Floor, New York, NY, 10010, USA. bolgerkelly9@gmail.com.
DeShannon BowensCenter for Drug Use and HIV Research (CDUHR), New York University College of Nursing, 433 First Avenue, 7th Floor, New York, NY, 10010, USA. dkbow@yahoo.com.
David PerlmanDepartment of Infectious Diseases, Mount Sinai Beth Israel, New York, NY, USA. perlman@chpnet.org.
Donna MildvanDepartment of Infectious Diseases, Mount Sinai Beth Israel, New York, NY, USA. dmildvan@chpnet.org.
Heart to Heart Collaborative Research Team
New York University · USMount Sinai Beth Israel · USColumbia University · USSpencer Foundation · USUniversity of California, San Francisco · US

Funding

WOMEN'S INTERAGENCY HIV STUDY ORGANIZATION, MANAGEMENT AND COMMUNICATIONSU01AI034989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, GREENBLATT, RUTH MARTHA · 1993 to 2018
$65.6M
Transdisciplinary Theoretical Svnthesis and Development CoreP30DA011041 · NIDA · NEW YORK UNIVERSITY · PI Holly Hagan · 1998 to 2026
$38.9M
Plugging Hair ARV Levels as Adherence Biomarkers into HIV Prevention TrialsR01AI098472 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GANDHI, MONICA · 2012 to 2021
$5.6M
“Hair Lengthening”: Using Hair Levels to Interpret Long-Acting PrEP Studies.R37AI098472 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 2023 to 2026
$3.2M
Intervention to Increase Timely Initiation of HAART Among Those Who Delay/DeclineR34MH093352 · NIMH · NEW YORK UNIVERSITY · PI GWADZ, MARYA · 2011 to 2013
$685k
NIAID NIH HHS R01 AI098472NIAID NIH HHS R01AI098472NIAID NIH HHS R37 AI098472NIAID NIH HHS U01 AI034989NIDA NIH HHS P30 DA011041NIMH NIH HHS R34 MH093352NIMH NIH HHS R34MH093352
6 · The paper itself

Abstract

Nationally up to 60 % of persons living with HIV are neither taking antiretroviral therapy (ART) nor well engaged in HIV care, mainly racial/ethnic minorities. This study examined a new culturally targeted multi-component intervention to address emotional, attitudinal, and social/structural barriers to ART initiation and HIV care. Participants (N = 95) were African American/Black and Latino adults with CD4 < 500 cells/mm(3) not taking ART, randomized 1:1 to intervention or control arms, the latter receiving treatment as usual. Primary endpoints were adherence, evaluated via ART concentrations in hair samples, and HIV viral load suppression. The intervention was feasible and acceptable. Eight months post-baseline, intervention participants tended to be more likely to evidence "good" (that is, 7 days/week) adherence (60 vs. 26.7 %; p = 0.087; OR = 3.95), and had lower viral load levels than controls (t(22) = 2.29, p = 0.032; OR = 5.20), both large effect sizes. This highly promising intervention merits further study.

Indexed as

Behavior TherapyMotivational InterviewingPatient ComplianceAdultAgedAnti-Retroviral AgentsBlack or African AmericanCD4 Lymphocyte CountContinuity of Patient CareFemaleFollow-Up StudiesHealthcare DisparitiesHispanic or LatinoHIV InfectionsHumansMaleAnti-Retroviral AgentsAntiretroviral therapyDisparitiesHIV/AIDSInterventionMotivational interviewing

Identifiers

PMID25835462
PMCPMC4567451
OpenAlexW2026979613

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.