Evidence map›Paper›PMID 25835263›Full record

ArticleOphthalmology2015

Association between Smoking and Uveitis: Results from the Pacific Ocular Inflammation Study.

Brenton G Yuen, Vivien M Tham, Erica N Browne, Rachel Weinrib, Durga S Borkar, John V Parker, Aileen Uchida, Aleli C Vinoya, Nisha R Acharya

Abstract read
In one paragraph

Article in Ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. The Immunopathogenesis of uveitis.Frontiers in medicine · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. The Adverse Effects of Air Pollution on the Eye: A Review.International journal of environmental research and public health · 2022
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Brenton G YuenF.I. Proctor Foundation, University of California, San Francisco, San Francisco, California; University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii.
Vivien M ThamUniversity of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii; Department of Ophthalmology, Kaiser Permanente Hawaii, Honolulu, Hawaii; Pacific Vision Institute of Hawaii, Honolulu, Hawaii.
Erica N BrowneF.I. Proctor Foundation, University of California, San Francisco, San Francisco, California.
Rachel WeinribF.I. Proctor Foundation, University of California, San Francisco, San Francisco, California.
Durga S BorkarF.I. Proctor Foundation, University of California, San Francisco, San Francisco, California.
John V ParkerCenter for Health Research, Kaiser Permanente Hawaii, Honolulu, Hawaii.
Aileen UchidaCenter for Health Research, Kaiser Permanente Hawaii, Honolulu, Hawaii.
Aleli C VinoyaCenter for Health Research, Kaiser Permanente Hawaii, Honolulu, Hawaii.
Nisha R AcharyaF.I. Proctor Foundation, University of California, San Francisco, San Francisco, California; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California; Department of Ophthalmology, University of California, San Francisco, San Francisco, California. Electronic address: nisha.acharya@ucsf.edu.

Funding

First-line Antimetabolites as Steroid-sparing Treatment (FAST) Uveitis TrialU10EY021125 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ACHARYA, NISHA · 2012 to 2016
$4.6M
NEURONAL INVOLVEMENT IN OCULAR HERPETIC DISEASEF32EY006190 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARGOLIS, TODD P. · 1989 to 1990
–
NEI NIH HHS EY06190NEI NIH HHS U10 EY021125NEI NIH HHS U10EY021125
6 · The paper itself

Abstract

purposeTo assess whether cigarette smoking is associated with the development of uveitis in a population-based setting.

designRetrospective, population-based, case-control study.

participantsPatients aged ≥ 18 years who were seen at a Kaiser Permanente Hawaii clinic between January 1, 2006, and December 31, 2007. Analysis included 100 confirmed incident uveitis cases, 522 randomly selected controls from the general Kaiser Hawaii population, and 528 randomly selected controls from the Kaiser Hawaii ophthalmology clinic.

methodsInternational Classification of Diseases, 9th revision (ICD-9), diagnosis codes were used to identify possible uveitis cases. A uveitis fellowship-trained ophthalmologist then conducted individual chart review to confirm case status. Multivariate logistic regression models were used to evaluate the association between smoking and uveitis, adjusting for age, sex, race, and socioeconomic status.

main outcome measuresDevelopment of uveitis.

resultsCurrent smokers had a 1.63 (95% confidence interval [CI], 0.88-3.00; P = 0.12) and 2.33 (95% CI, 1.22-4.45; P = 0.01) times greater odds of developing uveitis compared with those who never smoked using the general and ophthalmology control groups, respectively. The association was even stronger with noninfectious uveitis, which yielded odds ratios of 2.10 (95% CI, 1.10-3.99; P = 0.02) and 2.96 (95% CI, 1.52-5.77; P = 0.001) using the general and ophthalmology control groups, respectively.

conclusionsCigarette smoking is significantly associated with new-onset uveitis within a population-based setting. The association was stronger for noninfectious uveitis. Given the well-established risks of smoking with regard to other inflammatory disorders, these results reaffirm the importance of encouraging patients to avoid or cease smoking.

Indexed as

AdultAgedCase-Control StudiesDatabases, FactualEthnicityFemaleHawaiiHealth Maintenance OrganizationsHumansInternational Classification of DiseasesLogistic ModelsMaleMiddle AgedOdds RatioRetrospective StudiesRisk Factors

Identifiers

PMID25835263
PMCPMC4446169

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.