ReviewEvolution, medicine, and public health2015
Milk bioactives may manipulate microbes to mediate parent-offspring conflict.
Review in Evolution, medicine, and public health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 52 citations in OpenAlex.
- Associations among rearing environment and the infant gut microbiome with early-life neurodevelopment and cognitive development in a nonhuman primate model (Journal of developmental origins of health and disease · 2025Article
- Meager Milk: Lasting Consequences for Adult Daughters of Primiparous Mothers Among Rhesus Macaques (Macaca mulatta).Integrative and comparative biology · 2023Article
- The hidden universe of human milk microbiome: origin, composition, determinants, role, and future perspectives.European journal of pediatrics · 2022Review
- Article
- Age Patterning in Wild Chimpanzee Gut Microbiota Diversity Reveals Differences from Humans in Early Life.Current biology : CB · 2021Article
- The role of the microbiome in the neurobiology of social behaviour.Biological reviews of the Cambridge Philosophical Society · 2020Article
- Diversity and temporal dynamics of primate milk microbiomes.American journal of primatology · 2019Article
- A descriptive analysis of gut microbiota composition in differentially reared infant rhesus monkeys (Macaca mulatta) across the first 6 months of life.American journal of primatology · 2019Article
- Early Europeans bottle-fed babies with animal milk.Nature · 2019Article
- Human Milk Microbiome and Maternal Postnatal Psychosocial Distress.Frontiers in microbiology · 2019Article
- Are cortisol concentrations in human breast milk associated with infant crying?Developmental psychobiology · 2018Article
- Cortisol in Neonatal Mother's Milk Predicts Later Infant Social and Cognitive Functioning in Rhesus Monkeys.Child development · 2018Article
- Article
- Insights into human evolution from ancient and contemporary microbiome studies.Current opinion in genetics & development · 2016Review
- Sex differences in the gut microbiome-brain axis across the lifespan.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Animal-microbe interactions and the evolution of nervous systems.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Article
- The prebiotics 3'Sialyllactose and 6'Sialyllactose diminish stressor-induced anxiety-like behavior and colonic microbiota alterations: Evidence for effects on the gut-brain axis.Brain, behavior, and immunity · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among mammals, milk constituents directly influence the ecology of the infant's commensal microbiota. The immunological and nutritional impacts of breast milk and microbiota are increasingly well understood; less clear are the consequences for infant behavior. Here, we propose that interactions among bioactives in mother's milk and microbes in the infant gut contribute to infant behavioral phenotype and, in part, have the potential to mediate parent-offspring conflict. We hypothesize that infant behavior likely varies as a function of their mother's milk composition interacting with the infant's neurobiology directly and indirectly through the commensal gut bacteria. In this article, we will explore our hypothesis of a milk-microbiota-brain-behavior dynamic in the context of the coevolution between human milk oligosaccharides, bacteria, the gut-brain axis and behavior. Integrating established features of these systems allows us to generate novel hypotheses to motivate future research and consider potential implications of current and emerging clinical treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.