Evidence map›Paper›PMID 25834953›Full record

ReviewTrends in microbiology2015

Signaling and sensory adaptation in Escherichia coli chemoreceptors: 2015 update.

John S Parkinson, Gerald L Hazelbauer, Joseph J Falke

Open access · greenAbstract readReview
In one paragraph

Review in Trends in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 253 papers.

0numbers the graph read from it
0cells of the map it votes in
253citing papers in PubMed
27.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

253 citing papers in PubMed, 436 citations in OpenAlex.

  1. ThemBio · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Signaling mechanism of the transmembrane energy receptor Aer.bioRxiv : the preprint server for biology · 2026
    Article
  7. Growth-dependent sensory bet-hedging enhances collective navigation.bioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Article
  10. Review
  11. TheJournal of bacteriology · 2026
    Article
  12. Collective bacterial condensation is fundamentally constrained by the emergence of active turbulence.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Structure and signaling mechanism ofbioRxiv : the preprint server for biology · 2026
    Article
  18. Review
  19. Review
  20. Nature physics · 2026
    Article

193 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

John S ParkinsonDepartment of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112, USA. Electronic address: parkinson@biology.utah.edu.
Gerald L HazelbauerDepartment of Biochemistry, University of Missouri Columbia, Columbia, MO 65211, USA.
Joseph J FalkeDepartment of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA.
University of Colorado Boulder · USUniversity of Missouri · USUniversity of Utah · US

Funding

Intracellular Signaling by Bacterial ChemoreceptorsR01GM019559 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI JOHN S PARKINSON · 1985 to 2026
$12.3M
Molecular Studies of Chemoreception: Administrative Supplement for EquipmentR37GM029963 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI HAZELBAUER, GERALD L. · 2012 to 2021
$5.7M
MOLECULAR STUDIES OF CHEMORECEPTIONR01GM029963 · NIGMS · WASHINGTON STATE UNIVERSITY · PI HAZELBAUER, GERALD L. · 1985 to 2010
$4.2M
RECEPTORS &SIGNALING PROTEINS--DYNAMICS &ACTIVATIONR01GM040731 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI FALKE, JOSEPH J · 1988 to 2013
$3.4M
INTRACELLULAR SIGNALING BY BACTERIAL CHEMORECEPTORSR37GM019559 · NIGMS · UNIVERSITY OF UTAH · PI PARKINSON, JOHN S · 1992 to 2001
$806k
NIGMS NIH HHS GM19559NIGMS NIH HHS GM29963NIGMS NIH HHS GM40731NIGMS NIH HHS R01 GM019559NIGMS NIH HHS R01 GM029963NIGMS NIH HHS R01 GM040731NIGMS NIH HHS R37 GM019559NIGMS NIH HHS R37 GM029963
6 · The paper itself

Abstract

Motile Escherichia coli cells track gradients of attractant and repellent chemicals in their environment with transmembrane chemoreceptor proteins. These receptors operate in cooperative arrays to produce large changes in the activity of a signaling kinase, CheA, in response to small changes in chemoeffector concentration. Recent research has provided a much deeper understanding of the structure and function of core receptor signaling complexes and the architecture of higher-order receptor arrays, which, in turn, has led to new insights into the molecular signaling mechanisms of chemoreceptor networks. Current evidence supports a new view of receptor signaling in which stimulus information travels within receptor molecules through shifts in the dynamic properties of adjoining structural elements rather than through a few discrete conformational states.

Indexed as

ChemotaxisSignal TransductionBacterial ProteinsEscherichia coliEscherichia coli ProteinsHistidine KinaseMembrane ProteinsMethyl-Accepting Chemotaxis ProteinsModels, MolecularMutationProtein ConformationProtein Structure, TertiaryBacterial ProteinscheA protein, E coliEscherichia coli ProteinsHistidine KinaseMembrane ProteinsMethyl-Accepting Chemotaxis Proteinscooperative networkkinase controltransmembrane signaling

Identifiers

PMID25834953
PMCPMC4417406
OpenAlexW2074279517

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.