Evidence map›Paper›PMID 25834744›Full record

ArticleInternational journal of medicinal chemistry2015

Synthesis and biological activity of arylspiroborate salts derived from caffeic Acid phenethyl ester.

Martin J G Hébert, Andrew J Flewelling, Trevor N Clark, Natalie A Levesque, Jacques Jean-François, Marc E Surette, Christopher A Gray, Christopher M Vogels, Mohamed Touaibia, Stephen A Westcott

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medicinal chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Martin J G HébertDepartment of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada E1A 3E9.
Andrew J FlewellingDepartment of Biology, University of New Brunswick, Saint John, NB, Canada E2L 4L5.
Trevor N ClarkDepartment of Biology, University of New Brunswick, Saint John, NB, Canada E2L 4L5.
Natalie A LevesqueDepartment of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada E1A 3E9.ORCID 0000-0003-2383-8167
Jacques Jean-FrançoisDepartment of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada E1A 3E9.
Marc E SuretteDepartment of Biology, University of New Brunswick, Saint John, NB, Canada E2L 4L5.
Christopher A GrayDepartment of Biology, University of New Brunswick, Saint John, NB, Canada E2L 4L5 ; Department of Chemistry, University of New Brunswick, Fredericton, NB, Canada E3B 5A3.
Christopher M VogelsDepartment of Chemistry and Biochemistry, Mount Allison University, Sackville, NB, Canada E4L 1G8.
Mohamed TouaibiaDepartment of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada E1A 3E9.
Stephen A WestcottDepartment of Chemistry and Biochemistry, Mount Allison University, Sackville, NB, Canada E4L 1G8.
Université de Moncton · CAUniversity of New Brunswick · CAMount Allison University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two novel boron compounds containing caffeic acid phenethyl ester (CAPE) derivatives have been prepared and characterized fully. These new compounds and CAPE have been investigated for potential antioxidant and antimicrobial properties and their ability to inhibit 5-lipoxygenase and whether chelation to boron improves their biological activity. Sodium salt 4 was generally more active than ammonium salt 5 in the biological assays and surpassed the radical scavenging ability of CAPE. Compounds 4 and 5 were more active than CAPE and Zileuton in human polymorphonuclear leukocytes. These results clearly show the effectiveness of the synthesized salts as transporter of CAPE.

Identifiers

PMID25834744
PMCPMC4365380
OpenAlexW2062361113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.