Evidence map›Paper›PMID 25834502›Full record

ArticleAfrican health sciences2014

Association between mean platelet volume levels and inflammation in SLE patients presented with arthritis.

Sahin Safak, Ali Ugur Uslu, Korkmaz Serdal, Tasliyurt Turker, Senel Soner, Akyol Lutfi

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in African health sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04110184 (Haematological Indices in Systemic Lupus Erythematosus and Their Association With Disease Activity), which is not on this map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04110184 unknown statusnot on this mapstarted 2019, after this paper: background citation

Haematological Indices in Systemic Lupus Erythematosus and Their Association With Disease Activity

TypeobservationalSponsorAssiut UniversityRan2019 to 2023Enrolled84ConditionsRheumatic Diseases, Systemic Lupus ErythematosusArmsSystemic lupus erythematosus disease activity index (SLEDAI)
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  13. Can Complete Blood Count Picture Tell Us More About the Activity of Rheumatological Diseases?Clinical medicine insights. Arthritis and musculoskeletal disorders · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sahin SafakGaziosmanpasa University, Faculty of Medicine, Department of Internal Medicine, Tokat, Turkey.
Ali Ugur UsluCumhuriyet University, Faculty of Medicine, Department of Internal Medicine, Sivas, Turkey.
Korkmaz SerdalCumhuriyet University, Faculty of Medicine, Department of Internal Medicine, Sivas, Turkey.
Tasliyurt TurkerGaziosmanpasa University, Faculty of Medicine, Department of Internal Medicine, Tokat, Turkey.
Senel SonerErciyes University, Faculty of Medicine, Department of Rheumatology, Kayseri, Turkey.
Akyol LutfiBozok University, Faculty of Medicine, Department of Internal Medicine, Yozgat, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSystemic lupus erythematosus (SLE) may be characterized by periods of remissions and chronic or acute relapses. The complexity of clinical presentation of the SLE patients leads to incorrect evaluation of disease activity. Mean platelet volume (MPV) has been studied as a simple inflammatory marker in several diseases. There is no study in the literature about MPV levels in adult SLE patients with arthritis.

objectivesWe aimed to investigate the MPV levels in the SLE population with arthritis during and between activations.

methodsThe study consisted of 44 SLE patients with arthritis in activation period (Group 1), the same 44 SLE patients with arthritis in remission period (Group 2) and 44 healthy controls (Group 3). Erythrocyte sedimentation rate (ESR), creactive protein (CRP), white blood cell count, platelet count, and mean platelet volume (MPV) levels were retrospectively recorded from patient files.

resultsThe mean ages of the SLE subjects were 42 ± 16 years, while the mean ages of controls was 41 ± 17 years. MPV was significantly lower in Group 1(7.66±0.89fL) than in Group 2 (8.61±1.06 fL) and Group 3(8.62±1.11fL) (p<0.0001). The differences between groups reached statistical significance.

conclusionsWe suggest that MPV levels decrease in patients with arthritis of SLE activation when compared to the same patients in remission and healthy controls.

Indexed as

Blood SedimentationMean Platelet VolumeAdolescentAdultAgedArthritisBiomarkersCase-Control StudiesC-Reactive ProteinFemaleHumansInflammationLeukocyte CountLogistic ModelsLupus Erythematosus, SystemicMaleBiomarkersC-Reactive ProteinArthritisMean platelet volumeSystemic lupus erythematosus

Identifiers

PMID25834502
PMCPMC4370072

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.