Evidence map›Paper›PMID 25834453›Full record

ArticleTherapeutics and clinical risk management2015

Risk factors for osteoporosis in Japan: is it associated with Helicobacter pylori?

Daisuke Asaoka, Akihito Nagahara, Yuji Shimada, Kenshi Matsumoto, Hiroya Ueyama, Kohei Matsumoto, Yuta Nakagawa, Tsutomu Takeda, Ippei Tanaka, Hitoshi Sasaki and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutics and clinical risk management, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 4 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  7. Bone Fragility in Gastrointestinal Disorders.International journal of molecular sciences · 2022
    Review
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  14. Observational
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  16. Article
  17. Review
  18. Therapeutics and clinical risk management · 2017
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Daisuke AsaokaDepartment of Gastroenterology, University of Juntendo, School of Medicine, Tokyo, Japan.
Akihito NagaharaDepartment of Gastroenterology, University of Juntendo, School of Medicine, Tokyo, Japan.
Yuji ShimadaDepartment of Gastroenterology, University of Juntendo, School of Medicine, Tokyo, Japan.
Kenshi MatsumotoDepartment of Gastroenterology, University of Juntendo, School of Medicine, Tokyo, Japan.
Hiroya UeyamaDepartment of Gastroenterology, University of Juntendo, School of Medicine, Tokyo, Japan.
Kohei MatsumotoDepartment of Gastroenterology, University of Juntendo, School of Medicine, Tokyo, Japan.
Yuta NakagawaDepartment of Gastroenterology, University of Juntendo, School of Medicine, Tokyo, Japan.
Tsutomu TakedaDepartment of Gastroenterology, University of Juntendo, School of Medicine, Tokyo, Japan.
Ippei TanakaDepartment of Gastroenterology, University of Juntendo, School of Medicine, Tokyo, Japan.
Hitoshi SasakiDepartment of Gastroenterology, University of Juntendo, School of Medicine, Tokyo, Japan.
Taro OsadaDepartment of Gastroenterology, University of Juntendo, School of Medicine, Tokyo, Japan.
Mariko HojoDepartment of Gastroenterology, University of Juntendo, School of Medicine, Tokyo, Japan.
Sumio WatanabeDepartment of Gastroenterology, University of Juntendo, School of Medicine, Tokyo, Japan.
Juntendo University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA number of diseases and drugs may influence bone mineral density; however, there are few reports concerning the relationship between lifestyle-related diseases and osteoporosis in Japan as determined by multivariate analysis. The aim of this study was to investigate the risk factors for osteoporosis and whether infection by or eradication of Helicobacter pylori is associated with osteoporosis.

methodsBetween February 2008 and November 2014, using a cross-sectional study design, we investigated patient profile (age, sex, BMI, alcohol, smoking), H. pylori infection status, comorbidities, internal medicine therapeutic agents (calcium channel blocker, HMG-CoA reductase inhibitors, proton pump inhibitor), serum parameters (Hb, calcium, γGTP), bone turn over markers (bone-specific alkaline phosphatase (BAP) and collagen type I cross-linked N telopeptide (NTX), findings on dual-energy x-ray absorptiometry (DEXA) and upper gastrointestinal endoscopy, and Frequency Scale for the Symptoms of GERD score in consecutive outpatients aged ≥50 years at our hospital. We divided the subjects into an osteoporosis group and a non-osteoporosis group and investigated risk factors for osteoporosis between the two groups by bivariate and multivariate analyses.

resultsOf the 255 eligible study subjects, 43 (16.9%) had osteoporosis. Bivariate analysis showed that advanced age, female sex, lower body mass index, lower cumulative alcohol intake, lower Brinkman index, H. pylori positivity, lower hemoglobin, bone-specific alkaline phosphatase, lower prevalence of hiatal hernia, and endoscopic gastric mucosal atrophy were related to osteoporosis. Multivariate analysis showed that advanced age (odds ratio [OR] 1.13, 95% confidence interval [CI] 1.07-1.19, P<0.001), female sex (OR 6.27, 95% CI 2.26-17.39, P<0.001), low BMI (OR 0.82, 95% CI 0.72-0.94, P=0.005), H. pylori positivity (OR 3.00, 95% CI 1.31-6.88, P=0.009), and BAP (OR 1.07, 95% CI 1.01-1.14, P=0.035) were related to osteoporosis.

conclusionAdvanced age, low BMI, BAP, and H. pylori positivity were risk factors for osteoporosis; however, the success of H. pylori eradication was not a risk factor for osteoporosis in Japan.

Indexed as

eradicationHelicobacter pylorilifestyle diseaseosteoporosisproton pump inhibitorrisk factor

Identifiers

PMID25834453
PMCPMC4358368
OpenAlexW1969765453

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.