ArticleInternational journal of nanomedicine2015
Non-chemotoxic induction of cancer cell death using magnetic nanowires.
Article in International journal of nanomedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 114 citations in OpenAlex.
- Preparation and Evaluation of Docetaxel-Loaded Targeted Poly (β‑amino Ester) - Magnetic Nanoparticles for Chemo‑Magnetodynamic Therapy Under Low‑Frequency Magnetic Fields.International journal of nanomedicine · 2026Article
- Remote Control of Gold-Iron Nanowires Using Low-Frequency 1 Hz Magneto-Mechanical Therapy and Cesium 137 0.662 MeV Radiotherapy for Treatment of Glioblastoma Multiforme.ACS applied materials & interfaces · 2025Article
- Synergistic Effect of Chemotherapy and Magnetomechanical Actuation of Fe-Cr-Nb-B Magnetic Particles on Cancer Cells.ACS omega · 2024Article
- Feature Matching of Microsecond-Pulsed Magnetic Fields Combined with FeBiomolecules · 2024Article
- Electrodeposition as a Tool for Nanostructuring Magnetic Materials.Micromachines · 2022Review
- Low frequency vibrating magnetic field-triggered magnetic microspheres with a nanoflagellum-like surface for cancer therapy.Journal of nanobiotechnology · 2022Article
- Stochastic Magnetization Switching in Rapidly Solidified (CoMaterials (Basel, Switzerland) · 2022Article
- Magneto-mechanical destruction of cancer-associated fibroblasts using ultra-small iron oxide nanoparticles and low frequency rotating magnetic fields.Nanoscale advances · 2022Article
- Magneto-mechanical treatment of human glioblastoma cells with engineered iron oxide powder microparticles for triggering apoptosis.Nanoscale advances · 2021Article
- Information storage in permalloy modulated magnetic nanowires.Scientific reports · 2021Article
- Magnetic Nanodiscs-A New Promising Tool for Microsurgery of Malignant Neoplasms.Nanomaterials (Basel, Switzerland) · 2021Review
- Cancer treatment by magneto-mechanical effect of particles, a review.Nanoscale advances · 2020Review
- Multifunctional Magnetic Nanowires: Design, Fabrication, and Future Prospects as Cancer Therapeutics.Cancers · 2019Review
- Modeling magnetic-field-induced domain wall propagation in modulated-diameter cylindrical nanowires.Scientific reports · 2019Article
- Fe-Cr-Nb-B ferromagnetic particles with shape anisotropy for cancer cell destruction by magneto-mechanical actuation.Scientific reports · 2018Article
- Applications, Surface Modification and Functionalization of Nickel Nanorods.Materials (Basel, Switzerland) · 2017Review
- Multisegmented Nanowires: a Step towards the Control of the Domain Wall Configuration.Scientific reports · 2017Article
- Magnetic particles with perpendicular anisotropy for mechanical cancer cell destruction.Scientific reports · 2017Article
- Elongated Nanoparticle Aggregates in Cancer Cells for Mechanical Destruction with Low Frequency Rotating Magnetic Field.Theranostics · 2017Article
- Functionalized magnetic nanowires for chemical and magneto-mechanical induction of cancer cell death.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper, we show that magnetic nanowires with weak magnetic fields and low frequencies can induce cell death via a mechanism that does not involve heat production. We incubated colon cancer cells with two concentrations (2.4 and 12 μg/mL) of nickel nanowires that were 35 nm in diameter and exposed the cells and nanowires to an alternating magnetic field (0.5 mT and 1 Hz or 1 kHz) for 10 or 30 minutes. This low-power field exerted a force on the magnetic nanowires, causing a mechanical disturbance to the cells. Transmission electron microscopy images showed that the nanostructures were internalized into the cells within 1 hour of incubation. Cell viability studies showed that the magnetic field and the nanowires separately had minor deleterious effects on the cells; however, when combined, the magnetic field and nanowires caused the cell viability values to drop by up to 39%, depending on the strength of the magnetic field and the concentration of the nanowires. Cell membrane leakage experiments indicated membrane leakage of 20%, suggesting that cell death mechanisms induced by the nanowires and magnetic field involve some cell membrane rupture. Results suggest that magnetic nanowires can kill cancer cells. The proposed process requires simple and low-cost equipment with exposure to only very weak magnetic fields for short time periods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.