Evidence map›Paper›PMID 25834421›Full record

SynthesisInternational journal of chronic obstructive pulmonary disease2015

Comparison of laboratory- and field-based exercise tests for COPD: a systematic review.

Iain Fotheringham, Georgina Meakin, Yogesh Suresh Punekar, John H Riley, Sarah M Cockle, Sally J Singh

Registry-linked trialAbstract readComparative StudySystematic Review
In one paragraph

Synthesis in International journal of chronic obstructive pulmonary disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03675087 (Assessment of Exercise Response in Chronic Fatigue Syndrome / Myalgic Encephalomyelitis.), which is not on this map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03675087 recruitingnot on this mapstarted 2019, after this paper: background citation

Assessment of Exercise Response in Chronic Fatigue Syndrome / Myalgic Encephalomyelitis.

TypeobservationalSponsorEscuela Universitaria de Fisioterapia de la OnceRan2019 to 2025Enrolled22ConditionsFatigue Syndrome, Chronic
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Iain FotheringhamValue Demonstration Practice, Oxford PharmaGenesis, Oxford, University Hospitals of Leicester NHS Trust, Leicester, UK.
Georgina MeakinValue Demonstration Practice, Oxford PharmaGenesis, Oxford, University Hospitals of Leicester NHS Trust, Leicester, UK.
Yogesh Suresh PunekarGlaxoSmithKline, Uxbridge, University Hospitals of Leicester NHS Trust, Leicester, UK.
John H RileyGlaxoSmithKline, Uxbridge, University Hospitals of Leicester NHS Trust, Leicester, UK.
Sarah M CockleGlaxoSmithKline, Uxbridge, University Hospitals of Leicester NHS Trust, Leicester, UK.
Sally J SinghDepartment of Respiratory Medicine, University Hospitals of Leicester NHS Trust, Leicester, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exercise tests are often used to evaluate the functional status of patients with COPD. However, to the best of our knowledge, a comprehensive systematic comparison of these tests has not been performed. We systematically reviewed studies reporting the repeatability and/or reproducibility of these tests, and studies comparing their sensitivity to therapeutic intervention. A systematic review identified primary manuscripts in English reporting relevant data on the following exercise tests: 6-minute walk test (6MWT) and 12-minute walk test, incremental and endurance shuttle walk tests (ISWT and ESWT, respectively), incremental and endurance cycle ergometer tests, and incremental and endurance treadmill tests. We identified 71 relevant studies. Good repeatability (for the 6MWT and ESWT) and reproducibility (for the 6MWT, 12-minute walk test, ISWT, ESWT, and incremental cycle ergometer test) were reported by most studies assessing these tests, providing patients were familiarized with them beforehand. The 6MWT, ISWT, and particularly the ESWT were reported to be sensitive to therapeutic intervention. Protocol variations (eg, track layout or supplemental oxygen use) affected performance significantly in several studies. This review shows that while the validity of several tests has been established, for others further study is required. Future work will assess the link between these tests, physiological mechanisms, and patient-reported measures.

Indexed as

Exercise TestExercise ToleranceHealth StatusHumansLungPredictive Value of TestsPrognosisPulmonary Disease, Chronic ObstructiveReproducibility of ResultsSeverity of Illness Index12MWT6MWTCOPDcycle ergometer testrepeatabilityreproducibilityshuttle walk testwalk test

Identifiers

PMID25834421
PMCPMC4372024

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.