Evidence map›Paper›PMID 25834338›Full record

SynthesisWorld journal of gastroenterology2015

Association between cadherin-17 expression and pathological characteristics of gastric cancer: a meta-analysis.

Zi-Wen Long, Meng-Long Zhou, Jing-Wei Fu, Xian-Qun Chu, Ya-Nong Wang

Abstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Cadherin 17 and digestive cancers: from diagnostic to therapeutic opportunities.Journal of experimental & clinical cancer research : CR · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Cadherin-17 as a target for the immunoPET of adenocarcinoma.European journal of nuclear medicine and molecular imaging · 2024
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zi-Wen LongZi-Wen Long, Meng-Long Zhou, Ya-Nong Wang, Department of Gastric Cancer and Soft-tissue Sarcoma Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Meng-Long ZhouZi-Wen Long, Meng-Long Zhou, Ya-Nong Wang, Department of Gastric Cancer and Soft-tissue Sarcoma Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Jing-Wei FuZi-Wen Long, Meng-Long Zhou, Ya-Nong Wang, Department of Gastric Cancer and Soft-tissue Sarcoma Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Xian-Qun ChuZi-Wen Long, Meng-Long Zhou, Ya-Nong Wang, Department of Gastric Cancer and Soft-tissue Sarcoma Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Ya-Nong WangZi-Wen Long, Meng-Long Zhou, Ya-Nong Wang, Department of Gastric Cancer and Soft-tissue Sarcoma Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo construct a meta-analysis in order to examine the relationship between cadherin-17 (CDH17) and gastric cancer (GC).

methodsRelated articles were selected by searching the following English or Chinese electronic databases: CINAHL, MEDLINE, Science Citation Index, the Chinese Journal Full-Text, and the Weipu Journal. Newcastle-Ottawa Scale (NOS) criteria were used to ensure consistency in reviewing and reporting results. Statistical analyses were conducted with Version 12.0 STATA statistical software.

resultsUltimately, 11 articles, with a total of 2,120 GC patients, were found to be eligible for study inclusion. In comparisons of GC patients by TNM stage (III-IV vs I-II: OR = 2.35, 95%CI: 1.15-4.825, P = 0.019), histologic grade (3-4 vs 1-2: OR = 3.48, 95%CI: 1.36-8.92, P = 0.009), invasion grade (T3-4 vs T1-2: OR = 2.86; 95%CI: 1.69-4.83; P = 0.000), and lymph node metastasis (positive vs negative: OR = 2.64; 95%CI: 1.33-5.27; P = 0.006), it was found that CDH17 showed more positive expressions in each of the more severe cases. Country-stratified analyses from all four experimental subgroups showed that high CDH17 expression levels may be related to GC among Chinese and Korean populations (all P < 0.05), with the exception of the invasion grade T3-4 vs T1-2 comparison, where the relation only held among the Chinese population (OR = 2.86, 95%CI: 1.69-4.83, P = 0.000).

conclusionCollectively, the data reflects the capacity of CDH17 in tumor proliferation and metastasis among GC patients.

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorCadherinsCell ProliferationFemaleHumansLinear ModelsLymphatic MetastasisMaleMiddle AgedNeoplasm InvasivenessNeoplasm StagingOdds RatioRisk FactorsBiomarkers, TumorCadherinsCDH17 protein, humanCadherin 17Gastric cancerMeta-analysisProtein expression

Identifiers

PMID25834338
PMCPMC4375595

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.